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Purpose <p>The appropriate surgical approach for colon cancer (CC) in nonagenarian patients remains a subject of clinical debate. This study aimed to compare the short-term outcomes of laparoscopic (Lap) versus open (Open) surgery in patients aged ≥ 90&#xa0;years with resectable colon cancer.</p> Methods <p>This multi-institutional retrospective cohort study included oldest-old patientswith pathological Stage II/III CC who underwent elective surgery at 15 hospitals between 2011 and 2022. Patients with rectal cancer, Stage 0/I/IV disease, or emergency surgery were excluded. To address selection bias, inverse-probability-weighted regression adjustment and stabilized inverse probability of treatment weighting (sIPTW) were applied. The primary outcome was postoperative complications; secondary outcomes included overall survival (OS).</p> Results <p>Median age was 92&#xa0;years in both groups. Before adjustment, the Lap group had a higher proportion of female patients (<i>p</i> = 0.038) and lower ASA scores (<i>p</i> = 0.01). Laparoscopic surgery was associated with a significantly longer operative time (220 vs. 171&#xa0;min, <i>p</i> = 0.046) but less intraoperative blood loss (10 vs. 78&#xa0;mL, <i>p</i> &lt; 0.01). Postoperative complication rates were comparable (Lap: 31.8%, Open: 33.8%), while the Lap group had a significantly shorter hospital stay (13 vs. 17&#xa0;days, <i>p</i> &lt; 0.01). D3 lymph node dissection was more frequently performed in the Lap group (<i>p</i> &lt; 0.01). After sIPTW, overall survival did not differ significantly between groups (<i>p</i> = 0.61).</p> Conclusion <p>Both laparoscopic and open surgery are feasible options for selected nonagenarians with colon cancer. Laparoscopic surgery may offer benefits in terms of reduced blood loss and shorter hospitalization, despite longer operative times. Careful patient selection considering frailty and comorbidities is essential in determining the most appropriate surgical approach.</p>

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Surgical outcomes and patient selection in nonagenarians with colon cancer: a comparative multi-institutional study of laparoscopic and open approaches

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月27日

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  • Ryohei Shoji,
  • Fuminori Teraishi,
  • Satoe Takanaga,
  • Toshiharu Mitsuhashi,
  • Ryo Inada,
  • Toshiaki Toshima,
  • Tsuyoshi Ohtani,
  • Ryosuke Yoshida,
  • Naoto Hori,
  • Kaoru Shigemitsu,
  • Sumiharu Yamamoto,
  • Tetsushi Kubota,
  • Yuka Okano,
  • Tetsuji Nobuhisa,
  • Fumitaka Taniguchi,
  • Wataru Ishikawa,
  • Tatsuo Matsuda,
  • Tatsuo Umeoka,
  • Toshiyoshi Fujiwara

摘要

Purpose

The appropriate surgical approach for colon cancer (CC) in nonagenarian patients remains a subject of clinical debate. This study aimed to compare the short-term outcomes of laparoscopic (Lap) versus open (Open) surgery in patients aged ≥ 90 years with resectable colon cancer.

Methods

This multi-institutional retrospective cohort study included oldest-old patientswith pathological Stage II/III CC who underwent elective surgery at 15 hospitals between 2011 and 2022. Patients with rectal cancer, Stage 0/I/IV disease, or emergency surgery were excluded. To address selection bias, inverse-probability-weighted regression adjustment and stabilized inverse probability of treatment weighting (sIPTW) were applied. The primary outcome was postoperative complications; secondary outcomes included overall survival (OS).

Results

Median age was 92 years in both groups. Before adjustment, the Lap group had a higher proportion of female patients (p = 0.038) and lower ASA scores (p = 0.01). Laparoscopic surgery was associated with a significantly longer operative time (220 vs. 171 min, p = 0.046) but less intraoperative blood loss (10 vs. 78 mL, p < 0.01). Postoperative complication rates were comparable (Lap: 31.8%, Open: 33.8%), while the Lap group had a significantly shorter hospital stay (13 vs. 17 days, p < 0.01). D3 lymph node dissection was more frequently performed in the Lap group (p < 0.01). After sIPTW, overall survival did not differ significantly between groups (p = 0.61).

Conclusion

Both laparoscopic and open surgery are feasible options for selected nonagenarians with colon cancer. Laparoscopic surgery may offer benefits in terms of reduced blood loss and shorter hospitalization, despite longer operative times. Careful patient selection considering frailty and comorbidities is essential in determining the most appropriate surgical approach.