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Purpose <p>Esophagectomy for esophageal cancer carries high postoperative morbidity and mortality. Circulating dipeptidyl peptidase 3 (cDPP3) is a novel biomarker linked to organ failure in acute care. This study evaluates its prognostic value for predicting organ dysfunction and mortality post-esophagectomy.</p> Methods <p>This prospective, single-center study included 20 esophagectomy patients. cDPP3 levels were measured preoperatively and at 24, 72, 120, and 168&#xa0;h postoperatively using a Nexus IB10 Analyzer. Postoperative complications, including pneumonia, anastomotic insufficiency, and SOFA score-based organ dysfunction, were recorded. Correlation analysis assessed associations between cDPP3 levels and clinical outcomes.</p> Results <p>Among 20 patients, the most common complications were pneumonia (<i>n</i> = 12), sepsis (<i>n</i> = 17), and anastomotic insufficiency (<i>n</i> = 5). Elevated cDPP3 levels correlated with SOFA score increases ≥ 2 (<i>p</i> &lt; 0.01) and severe complications, including prolonged ICU stays. cDPP3 levels at 72&#xa0;h were significantly associated with anastomotic insufficiency (<i>p</i> &lt; 0.01). A negative correlation was observed between intraoperative volume and cDPP3 levels at 24&#xa0;h (<i>r</i> = -0.495, <i>p</i> = 0.03).</p> Conclusions <p>cDPP3 is a potential biomarker for postoperative complications after esophagectomy. Its elevation correlates with increased morbidity, highlighting the need for vigilant perioperative management.</p>

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Elevated circulating dipeptidyl peptidase 3 (cDPP3) as a predictor of postoperative complications in esophagectomy patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月20日

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  • Valerie Isabel Nottberg,
  • Christine Marie Torrey,
  • Courtney Metz,
  • Natasha Irene Schweitzer,
  • Simone Schewe,
  • Mara R. Goetz,
  • Matthias Reeh,
  • Jakob R. Izbicki,
  • Jan Bardenhagen,
  • Asmus Heumann

摘要

Purpose

Esophagectomy for esophageal cancer carries high postoperative morbidity and mortality. Circulating dipeptidyl peptidase 3 (cDPP3) is a novel biomarker linked to organ failure in acute care. This study evaluates its prognostic value for predicting organ dysfunction and mortality post-esophagectomy.

Methods

This prospective, single-center study included 20 esophagectomy patients. cDPP3 levels were measured preoperatively and at 24, 72, 120, and 168 h postoperatively using a Nexus IB10 Analyzer. Postoperative complications, including pneumonia, anastomotic insufficiency, and SOFA score-based organ dysfunction, were recorded. Correlation analysis assessed associations between cDPP3 levels and clinical outcomes.

Results

Among 20 patients, the most common complications were pneumonia (n = 12), sepsis (n = 17), and anastomotic insufficiency (n = 5). Elevated cDPP3 levels correlated with SOFA score increases ≥ 2 (p < 0.01) and severe complications, including prolonged ICU stays. cDPP3 levels at 72 h were significantly associated with anastomotic insufficiency (p < 0.01). A negative correlation was observed between intraoperative volume and cDPP3 levels at 24 h (r = -0.495, p = 0.03).

Conclusions

cDPP3 is a potential biomarker for postoperative complications after esophagectomy. Its elevation correlates with increased morbidity, highlighting the need for vigilant perioperative management.