Objective <p>To study the clinical effect of laparoscopic temporary long-tunneled external ventricular drainage(LT-LTEVD) and conventional laparoscopic ventriculoperitoneal shunt(CL-VPS) in patients with post-traumatic brain injury hydrocephalus(PTH).</p> Methods <p>This study was a prospective study. We analyzed the clinical data of 52 patients with PTH admitted to our department from October 2018 to October 2021.All cases were randomly divided into two groups, and performed LT-LTEVD and CL-VPS respectively. The catheterization time, remission time of intracranial hypertension, hospital stay, therapeutic effectiveness and complications rate were compared between groups.</p> Results <p>The therapeutic effect of LT-LTEVD group (92.31%) was higher to that of CL-VPS group(65.38%), with statistical significance. Except the catheterization time, remission time of intracranial hypertension and hospital stay of CL-VPS group were significantly higher to those of the LT-LTEVD group, with statistical significance. The incidence of complications such as intracranial infection, shunt, obstruction and poor healing in the CL-VPS group(30.77%) was higher than that in LT-LTEVD group(7.69%), with statistical significance.</p> Conclusion <p>The preliminary results of this study showed that in the treatment of patients with PTH, LT-LTEVD could potentially have a positive effect. However, future researches are needed to clarify these preliminary results.</p>