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Purpose <p>To examine the effects of differently structured exercise programs (strength training (ST) vs endurance training (ET) vs a control group (CG)) on glucose metabolism and weight loss following Roux-en-Y Gastric Bypass (RYGB).</p> Methods <p>After RYGB, patients were randomized to a standardized ST or ET program or a control group, the intervention started within 28&#xa0;days. Outcomes at 6&#xa0;months were glucose and lipid metabolism, anthropometrics, inflammation, and quality of life.</p> Results <p>93 patients were randomized (30 in ST and 31 in ET, 32 in CG; 28% with type 2 diabetes mellitus, 8.5% insulin-dependent). Total weight was − 2.5&#xa0;kg (95% CI − 4.7 to − 0.4, p = 0.023) lower in pooled intervention group (PIG) and fat mass according to bioelectrical impedance analysis was − 3.0&#xa0;kg (95% CI − 5.0 to − 1.0, p = 0.0037) lower in the PIG. Fat-free mass decreased by − 4.2&#xa0;kg with no difference between the groups. The primary endpoint, glucose concentration after a 2&#xa0;h oral glucose tolerance test, did not differ between the PIG and the CG, − 0.29&#xa0;mmol/L (95% CI − 1.22 to 0.63, p = 0.54). Similarly, we did not detect any differences in lipid metabolism, inflammation, and quality of life between the groups.</p> Conclusion <p>In our study, we found that an additional exercise training 6&#xa0;months postoperatvely- independent of the type of training- resulted in greater weight loss and loss of fat mass. However, it had no effect on glucose/lipid parameters or inflammation beyond the surgery itself.</p>

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The effect of 6 months of structured strength or endurance exercise program on weight loss after gastric bypass surgery in a randomized controlled trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月14日

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  • Stefanie Lehmann,
  • Undine Gabriele Lange,
  • Andreas Oberbach,
  • Ulf Retschlag,
  • Roland Morgenroth,
  • Harald Busse,
  • Christiane Prettin,
  • David Petroff,
  • Lena Seidemann,
  • Matthias Blüher,
  • Arne Dietrich

摘要

Purpose

To examine the effects of differently structured exercise programs (strength training (ST) vs endurance training (ET) vs a control group (CG)) on glucose metabolism and weight loss following Roux-en-Y Gastric Bypass (RYGB).

Methods

After RYGB, patients were randomized to a standardized ST or ET program or a control group, the intervention started within 28 days. Outcomes at 6 months were glucose and lipid metabolism, anthropometrics, inflammation, and quality of life.

Results

93 patients were randomized (30 in ST and 31 in ET, 32 in CG; 28% with type 2 diabetes mellitus, 8.5% insulin-dependent). Total weight was − 2.5 kg (95% CI − 4.7 to − 0.4, p = 0.023) lower in pooled intervention group (PIG) and fat mass according to bioelectrical impedance analysis was − 3.0 kg (95% CI − 5.0 to − 1.0, p = 0.0037) lower in the PIG. Fat-free mass decreased by − 4.2 kg with no difference between the groups. The primary endpoint, glucose concentration after a 2 h oral glucose tolerance test, did not differ between the PIG and the CG, − 0.29 mmol/L (95% CI − 1.22 to 0.63, p = 0.54). Similarly, we did not detect any differences in lipid metabolism, inflammation, and quality of life between the groups.

Conclusion

In our study, we found that an additional exercise training 6 months postoperatvely- independent of the type of training- resulted in greater weight loss and loss of fat mass. However, it had no effect on glucose/lipid parameters or inflammation beyond the surgery itself.