Objective <p>To study the effect of transversus abdominis plane (TAP) block under direct vision with acupoint injection on the rapid recovery of patients after laparoscopic cholecystectomy.</p> Methods <p>Ninety-three patients undergoing laparoscopic cholecystectomy at Hangzhou Hospital of Traditional Chinese Medicine from January 2023 to December 2023 were selected and divided into control, TAP block under direct vision (TAP-DV), and TAP-DV with acupoint injection (TAP-DVA) groups using a random number table method. Postoperative VAS, Ramsay score, IL-6, CRP, and postoperative rehabilitation indices were compared among the three groups.</p> Results <p>The VAS pain score at 6&#xa0;h after surgery was significantly lower in the TAP-DV and TAP-DVA groups than in the control group (P &lt; 0.05). The VAS pain score at 24&#xa0;h after surgery was significantly lower in the TAP-DV and TAP-DVA groups than in the control group (P &lt; 0.05) and was significantly lower in the TAP-DVA group than in the TAP-DV group (P &lt; 0.05). The VAS pain score 48&#xa0;h after surgery was significantly lower in the TAP-DVA group than in the control and TAP-DV groups (P &lt; 0.05). The mean IL-6 level was significantly lower in the TAP-DVA and TAP-DV groups than in the control group (P &lt; 0.05). The postoperative nausea and vomiting rate was significantly lower in the TAP-DVA group than in the control group (P &lt; 0.05). The postoperative exhaust time was earlier in the TAP-DV and TAP-DVA groups than in the control group (P &lt; 0.05) and was earlier in the TAP-DVA group than in the TAP group (P &lt; 0.05). The postoperative hospitalization days and total cost were significantly lower in the TAP-DV and TAP-DVA groups than in the control group (P &lt; 0.05).</p> Conclusion <p>TAP-DVA has a stable and good analgesic effect and can promote rapid recovery after laparoscopic cholecystectomy.</p>