Development of a tool to calculate the probability of hypocalcemia after total thyroidectomy: a prospective study

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发表日期：

2024年1月9日

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Carlos Segundo Paiva Soares,
Katia Hiromoto Koga,
Sonia Marta Moriguchi,
Simone Antunes Terra,
José Vicente Tagliarini,
Pedro Henrique Dalmolin de Vasconcelos Affonso,
Monise da Silva Pechutti,
Gláucia Maria Ferreira da Silva Mazeto

摘要

Purpose

This study aimed to evaluate the ability of the percentage of decrease in serum PTH level in the first 8 h after total thyroidectomy (TT) to predict hypocalcemia requiring Ca supplementation and develop a tool to predict it.

Methods

97 patients who underwent TT with measurement of preoperative parathyroid hormone (PTH) levels were prospectively evaluated 1 and 8 h after TT; postoperative magnesium (Mg2PO) and phosphorus levels were evaluated on the 2nd day after surgery. The percentage of decrease in PTH level 1 h (%dPTH1h) and 8 h (%dPTH8h) postoperatively and predictors of hypocalcemia requiring Ca supplementation were evaluated and an equation was developed to predict this outcome.

Results

%dPTH1h (p = 0.002), %dPTH8h (p = 0.001) and (Mg2PO) (p < 0.01) were isolated predictors of postoperative hypocalcemia requiring Ca supplementation. The data obtained led to the development of two tools to predict this complication.

Conclusions

The percentage of decrease in PTH level 1 h and 8 h postoperatively and the magnesium level on the 2nd day after surgery were predictors of more severe hypocalcemia, and an auxiliary tool for predicting this complication was developed.