Scholarlink

Purpose <p>Mountain ultra-marathons (MUM) impose multiple stressors on pulmonary function inducing risk of airway epithelial damage. This study aimed to assess the magnitude of pulmonary function changes and the associated risks of airway damage induced by such a race.</p> Methods <p>Thirteen volunteers completed the MUM (330&#xa0;km, 24,000&#xa0;m elevation gain). Pulmonary function was assessed using standardized procedures before (pre-) and within 1&#xa0;h after (post-) the race. Assessments included forced inhalation and exhalation maneuvers, as well as maximal inspiratory pressure (MIP) measurements. Venous blood samples were collected for the analysis of plasma club cell secretory protein 16 (CC16). Blood volume was determined using the carbon monoxide rebreathing method.</p> Results <p>From pre- to post-, forced vital capacity (FVC) (-7.5%, <i>p</i> = 0.001), forced expiratory volume in 1&#xa0;s (FEV<sub>1</sub>) (-12.2%, <i>p</i> = 0.002) and peak expiratory flow (-10.4%, <i>p</i> = 0.016) were reduced. MIP decreased by 14.5% (104 ± 29 vs. 90 ± 26 cmH₂O, <i>p</i> = 0.005). CC16 levels remained unchanged, even after normalization for plasma volume changes (<i>p</i> = 0.929). Slope ratio and β-angle of the maximal expiratory flow-volume curve changes were not significant (<i>p</i> = 0.101 and <i>p</i> = 0.055, respectively). Significant relationships showed that greater decreases in FVC (<i>r</i> = − 0.60, <i>p</i> = 0.026) and FEV₁ (<i>r</i> = − 0.62, <i>p</i> = 0.018) were associated with faster MUM completion times.</p> Conclusion <p>The acute negative impact of MUM on pulmonary function has been confirmed. The extent of this impairment appears to be proportional to race duration. Biomarker analysis suggests that airway epithelial integrity remains preserved. The reduced pulmonary function could be due to respiratory muscle fatigue.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Lung function decline after mountain ultra-marathon is accompanied by reduced inspiratory pressure but not by detectable changes in CC16

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月21日

查看全文
  • Antoine Raberin,
  • Bastien Krumm,
  • Tom Citherlet,
  • Guia Tagliapietra,
  • Tadej Debevec,
  • Vincent Pialoux,
  • Grégoire P. Millet

摘要

Purpose

Mountain ultra-marathons (MUM) impose multiple stressors on pulmonary function inducing risk of airway epithelial damage. This study aimed to assess the magnitude of pulmonary function changes and the associated risks of airway damage induced by such a race.

Methods

Thirteen volunteers completed the MUM (330 km, 24,000 m elevation gain). Pulmonary function was assessed using standardized procedures before (pre-) and within 1 h after (post-) the race. Assessments included forced inhalation and exhalation maneuvers, as well as maximal inspiratory pressure (MIP) measurements. Venous blood samples were collected for the analysis of plasma club cell secretory protein 16 (CC16). Blood volume was determined using the carbon monoxide rebreathing method.

Results

From pre- to post-, forced vital capacity (FVC) (-7.5%, p = 0.001), forced expiratory volume in 1 s (FEV1) (-12.2%, p = 0.002) and peak expiratory flow (-10.4%, p = 0.016) were reduced. MIP decreased by 14.5% (104 ± 29 vs. 90 ± 26 cmH₂O, p = 0.005). CC16 levels remained unchanged, even after normalization for plasma volume changes (p = 0.929). Slope ratio and β-angle of the maximal expiratory flow-volume curve changes were not significant (p = 0.101 and p = 0.055, respectively). Significant relationships showed that greater decreases in FVC (r = − 0.60, p = 0.026) and FEV₁ (r = − 0.62, p = 0.018) were associated with faster MUM completion times.

Conclusion

The acute negative impact of MUM on pulmonary function has been confirmed. The extent of this impairment appears to be proportional to race duration. Biomarker analysis suggests that airway epithelial integrity remains preserved. The reduced pulmonary function could be due to respiratory muscle fatigue.