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Objective <p>To summarize physiological mechanisms linking exercise-induced magnesium (Mg<sup>2</sup>⁺) imbalance to electrophysiological instability in athletes, discuss limitations of serum-based assessment, and propose a conceptual framework for rapid point-of-care magnesium monitoring.</p> Data sources <p>Peer-reviewed evidence from exercise physiology, sports medicine, cardiovascular electrophysiology, and biosensing/wearable-technology literature indexed in PubMed, Scopus, and Web of Science.</p> Study selection <p>Studies addressing magnesium loss during exercise (sweat and renal excretion), intracellular Mg<sup>2</sup>⁺ physiology, repolarization dynamics (including QT modulation), arrhythmogenic mechanisms, and analytic approaches for rapid or wearable electrolyte assessment.</p> Data extraction <p>Key findings were synthesized regarding Mg<sup>2</sup>⁺ homeostasis, limitations of conventional biomarkers, feasibility of point-of-care monitoring, and implications for athlete physiological monitoring.</p> Data synthesis <p>Intense exercise may promote transient Mg<sup>2</sup>⁺ fluctuations, potentially affecting intracellular availability while serum Mg<sup>2</sup>⁺ remains within normal limits. Transient Mg<sup>2</sup>⁺ depletion may influence cardiac repolarization dynamics and contribute to electrophysiological vulnerability during intense exertion. Current screening strategies primarily identify structural or baseline electrical abnormalities and do not capture acute metabolic–electrolyte vulnerability during exertion. Emerging minimally invasive and wearable biosensors may enable rapid Mg<sup>2</sup>⁺ assessment and support broader physiological monitoring strategies in athletic settings.</p> Conclusions <p>Integrating rapid Mg<sup>2</sup>⁺ monitoring into athlete physiological assessment frameworks may complement existing screening approaches by providing additional insight into acute metabolic and electrolyte-related stress during training and competition.</p> <p>Validation studies assessing analytic accuracy, correlation with intracellular markers, and prospective field implementation are required for clinical translation.</p>

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Point-of-care magnesium monitoring in athletes: a physiological framework for exercise-related arrhythmic vulnerability

  • 期刊论文

  • 发表日期：

    2026年7月11日

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  • Ana Lúcia Abdo Ladeira

摘要

Objective

To summarize physiological mechanisms linking exercise-induced magnesium (Mg2⁺) imbalance to electrophysiological instability in athletes, discuss limitations of serum-based assessment, and propose a conceptual framework for rapid point-of-care magnesium monitoring.

Data sources

Peer-reviewed evidence from exercise physiology, sports medicine, cardiovascular electrophysiology, and biosensing/wearable-technology literature indexed in PubMed, Scopus, and Web of Science.

Study selection

Studies addressing magnesium loss during exercise (sweat and renal excretion), intracellular Mg2⁺ physiology, repolarization dynamics (including QT modulation), arrhythmogenic mechanisms, and analytic approaches for rapid or wearable electrolyte assessment.

Data extraction

Key findings were synthesized regarding Mg2⁺ homeostasis, limitations of conventional biomarkers, feasibility of point-of-care monitoring, and implications for athlete physiological monitoring.

Data synthesis

Intense exercise may promote transient Mg2⁺ fluctuations, potentially affecting intracellular availability while serum Mg2⁺ remains within normal limits. Transient Mg2⁺ depletion may influence cardiac repolarization dynamics and contribute to electrophysiological vulnerability during intense exertion. Current screening strategies primarily identify structural or baseline electrical abnormalities and do not capture acute metabolic–electrolyte vulnerability during exertion. Emerging minimally invasive and wearable biosensors may enable rapid Mg2⁺ assessment and support broader physiological monitoring strategies in athletic settings.

Conclusions

Integrating rapid Mg2⁺ monitoring into athlete physiological assessment frameworks may complement existing screening approaches by providing additional insight into acute metabolic and electrolyte-related stress during training and competition.

Validation studies assessing analytic accuracy, correlation with intracellular markers, and prospective field implementation are required for clinical translation.