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<p>High-intensity exercise (HIE) improves cardiorespiratory fitness but also acutely increases autonomic and hemodynamic stress in hypertensive individuals. L-citrulline augments nitric-oxide bioavailability and buffers these responses. We conducted a robust crossover trial in untreated hypertensive males (<i>n</i> = 12) to test whether short-term L-citrulline supplementation (6&#xa0;g·day⁻¹ for 6 days) modifies cardio-autonomic and hemodynamic responses after HIE. Heart-rate variability (HRV), systolic blood pressure [SBP], diastolic blood pressure [DBP], mean arterial pressure [MAP]), heart rate (HR), pulse pressure (PP), and rate-pressure product (RPP) were assessed. Mixed-effects modelling indicated that L-citrulline improved cardio-autonomic regulation: high-frequency power (HF, an index of vagal modulation) was higher at rest and at 90-min recovery; time-domain index standard deviation of normal-to-normal intervals (SDNN, representing overall autonomic activity) was increased at rest; and low-frequency power (LF) and LF/HF ratios were lower across time (condition and condition × time effects, all <i>p</i> ≤ 0.005). L-citrulline reduced SBP at rest (− 18.7 mmHg, <i>p</i> ≤ 0.005) and immediately after exercise (− 26.3 mmHg, <i>p</i> ≤ 0.005); DBP and MAP were lower across the recovery period (all <i>p</i> &lt; 0.001). HR was reduced from 15 to 90&#xa0;min post-exercise values (<i>p</i> ≤ 0.005), and RPP was lower immediately post-exercise (<i>p</i> ≤ 0.005), indicating reduced myocardial oxygen demand during this period. PP was lower immediately post-exercise (<i>p</i> ≤ 0.005). Supplementation with L-citrulline for six days enhanced cardiovascular recovery after HIE by blunting surges in cardiac, and BP workload, and may assist in improving the clinical efficacy of HIE in hypertensive subjects.</p>

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Short-term administration of L-citrulline augments cardiac vagal control and reduces blood pressure in response to high-intensity exercise in untreated hypertensive males

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • Zhara Hosseini Moghadam Boroujeny,
  • Mohammad Soltani,
  • Minoo Bassami,
  • James Derek Kingsley,
  • Fateme Sadat Farizani,
  • Sajad Ahamadizad,
  • Ismail Laher

摘要

High-intensity exercise (HIE) improves cardiorespiratory fitness but also acutely increases autonomic and hemodynamic stress in hypertensive individuals. L-citrulline augments nitric-oxide bioavailability and buffers these responses. We conducted a robust crossover trial in untreated hypertensive males (n = 12) to test whether short-term L-citrulline supplementation (6 g·day⁻¹ for 6 days) modifies cardio-autonomic and hemodynamic responses after HIE. Heart-rate variability (HRV), systolic blood pressure [SBP], diastolic blood pressure [DBP], mean arterial pressure [MAP]), heart rate (HR), pulse pressure (PP), and rate-pressure product (RPP) were assessed. Mixed-effects modelling indicated that L-citrulline improved cardio-autonomic regulation: high-frequency power (HF, an index of vagal modulation) was higher at rest and at 90-min recovery; time-domain index standard deviation of normal-to-normal intervals (SDNN, representing overall autonomic activity) was increased at rest; and low-frequency power (LF) and LF/HF ratios were lower across time (condition and condition × time effects, all p ≤ 0.005). L-citrulline reduced SBP at rest (− 18.7 mmHg, p ≤ 0.005) and immediately after exercise (− 26.3 mmHg, p ≤ 0.005); DBP and MAP were lower across the recovery period (all p < 0.001). HR was reduced from 15 to 90 min post-exercise values (p ≤ 0.005), and RPP was lower immediately post-exercise (p ≤ 0.005), indicating reduced myocardial oxygen demand during this period. PP was lower immediately post-exercise (p ≤ 0.005). Supplementation with L-citrulline for six days enhanced cardiovascular recovery after HIE by blunting surges in cardiac, and BP workload, and may assist in improving the clinical efficacy of HIE in hypertensive subjects.