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Purpose <p>This study investigated whether intermittent hypoxic exposure following resistance exercise mitigates acute vascular dysfunction. The main objective was to assess the effects of post-exercise hypoxia on flow-mediated dilation (FMD), blood pressure, and brachial-ankle pulse wave velocity (baPWV) in untrained males.</p> Methods <p>Thirteen untrained male university students (age: 20.46 ± 0.87&#xa0;years; body mass index: 23.6 ± 0.67&#xa0;kg/m<sup>2</sup>) participated in a crossover trial involving three experimental conditions: (1) resistance exercise followed by normoxia (RE, FIO<sub>2</sub> = 21%), (2) resistance exercise followed by intermittent hypoxia (RE-H1, alternating FIO<sub>2</sub> = 13.6% and 21%), and (3) resistance exercise followed by mild intermittent hypoxia (RE-H2, alternating FIO<sub>2</sub> = 15.8% and 21%). Participants performed five sets of 10 leg extensions at 70% of their one-repetition maximum. FMD, blood pressure, and baPWV were measured at baseline and 0, 10, 20, 30, and 60&#xa0;min post-exercise.</p> Results <p>Post-exercise systolic blood pressure decreased in all conditions (<i>p</i> &lt; 0.05), with no significant differences between conditions, while diastolic blood pressure showed no significant changes (<i>p</i> &gt; 0.05). baPWV decreased in RE and RE-H2 (<i>p</i> &lt; 0.05) but not in RE-H1, with RE showing greater reductions than RE-H1 (<i>p</i> &lt; 0.05). Blood flow and shear rates increased in all conditions (<i>p</i> &lt; 0.05), with greater responses in RE-H1 and RE-H2 (<i>p</i> &lt; 0.05). FMD decreased after RE (<i>p</i> &lt; 0.05) but was maintained in RE-H1 and RE-H2 for 60&#xa0;min post-exercise. The %FMD/Δ shear rate remained consistently higher in RE-H1 and RE-H2 than in RE throughout the post-exercise period (<i>p</i> &lt; 0.05).</p> Conclusion <p>Intermittent hypoxia following resistance exercise appears to preserve endothelial function and prevent transient vascular impairment, suggesting its potential as a recovery-enhancing strategy.</p>

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Vascular function responses to resistance exercise followed by intermittent hypoxic exposure in untrained males

  • 期刊论文

  • 发表日期：

    2025年8月29日

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  • Witid Mitranun,
  • Chaiyawat Namboonlue,
  • Nattha Muangritdech,
  • Kampanart Paditsaeree

摘要

Purpose

This study investigated whether intermittent hypoxic exposure following resistance exercise mitigates acute vascular dysfunction. The main objective was to assess the effects of post-exercise hypoxia on flow-mediated dilation (FMD), blood pressure, and brachial-ankle pulse wave velocity (baPWV) in untrained males.

Methods

Thirteen untrained male university students (age: 20.46 ± 0.87 years; body mass index: 23.6 ± 0.67 kg/m2) participated in a crossover trial involving three experimental conditions: (1) resistance exercise followed by normoxia (RE, FIO2 = 21%), (2) resistance exercise followed by intermittent hypoxia (RE-H1, alternating FIO2 = 13.6% and 21%), and (3) resistance exercise followed by mild intermittent hypoxia (RE-H2, alternating FIO2 = 15.8% and 21%). Participants performed five sets of 10 leg extensions at 70% of their one-repetition maximum. FMD, blood pressure, and baPWV were measured at baseline and 0, 10, 20, 30, and 60 min post-exercise.

Results

Post-exercise systolic blood pressure decreased in all conditions (p < 0.05), with no significant differences between conditions, while diastolic blood pressure showed no significant changes (p > 0.05). baPWV decreased in RE and RE-H2 (p < 0.05) but not in RE-H1, with RE showing greater reductions than RE-H1 (p < 0.05). Blood flow and shear rates increased in all conditions (p < 0.05), with greater responses in RE-H1 and RE-H2 (p < 0.05). FMD decreased after RE (p < 0.05) but was maintained in RE-H1 and RE-H2 for 60 min post-exercise. The %FMD/Δ shear rate remained consistently higher in RE-H1 and RE-H2 than in RE throughout the post-exercise period (p < 0.05).

Conclusion

Intermittent hypoxia following resistance exercise appears to preserve endothelial function and prevent transient vascular impairment, suggesting its potential as a recovery-enhancing strategy.