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Purpose <p>This study aimed to examine the acute effects of continuous and interval cycling on salivary secretory immunoglobulin A (SIgA) and anti-microbial peptides.</p> Methods <p>In a randomized crossover trial, 12 healthy young untrained men (22 ± 1&#xa0;years) performed two exercise patterns: continuous exercise (CE) for 20-min cycling load equivalent to 70% maximal oxygen uptake (V·O<sub>2max</sub>) and interval exercise (IE) for 20-min cycling exercise, with five sets of 2&#xa0;min at 50% V·O<sub>2max</sub> and five sets of 2&#xa0;min at 90% V·O<sub>2max</sub>. Saliva samples were collected at baseline and post-0&#xa0;min and post-30&#xa0;min after exercise. We evaluated salivary SIgA as well as salivary lysozyme, lactoferrin, human β-defensin-2, and LL-37 as the anti-microbial peptides at each time point.</p> Results <p>In the CE trial, the salivary SIgA secretion rate decreased immediately after exercise (p = 0.0002). However, in the IE trial, the salivary SIgA secretion rate did not change. In addition, the percentage change in salivary SIgA secretion rate immediately after exercise decreased in the CE as compared to the IE (CE: −37.6 ± 19.7% vs IE: 3.6 ± 33.6%, p = 0.0014). However, salivary lysozyme, lactoferrin, human β-defensin-2, and LL-37 secretion rates did not change from baseline to after exercise in both trials.</p> Conclusion <p>These results suggest that salivary SIgA secretion may differ between acute CE and IE, whereas secretory responses to salivary anti-microbial peptides may not differ.</p>

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Acute effects of continuous and interval cycling on salivary SIgA and anti-microbial peptide secretions: a randomized crossover trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月14日

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  • Reita Ito,
  • Masataka Uchida,
  • Shumpei Fujie,
  • Keiko Iemitsu,
  • Chihiro Kojima,
  • Yasushi Shinohara,
  • Takeshi Hashimoto,
  • Tadao Isaka,
  • Motoyuki Iemitsu

摘要

Purpose

This study aimed to examine the acute effects of continuous and interval cycling on salivary secretory immunoglobulin A (SIgA) and anti-microbial peptides.

Methods

In a randomized crossover trial, 12 healthy young untrained men (22 ± 1 years) performed two exercise patterns: continuous exercise (CE) for 20-min cycling load equivalent to 70% maximal oxygen uptake (V·O2max) and interval exercise (IE) for 20-min cycling exercise, with five sets of 2 min at 50% V·O2max and five sets of 2 min at 90% V·O2max. Saliva samples were collected at baseline and post-0 min and post-30 min after exercise. We evaluated salivary SIgA as well as salivary lysozyme, lactoferrin, human β-defensin-2, and LL-37 as the anti-microbial peptides at each time point.

Results

In the CE trial, the salivary SIgA secretion rate decreased immediately after exercise (p = 0.0002). However, in the IE trial, the salivary SIgA secretion rate did not change. In addition, the percentage change in salivary SIgA secretion rate immediately after exercise decreased in the CE as compared to the IE (CE: −37.6 ± 19.7% vs IE: 3.6 ± 33.6%, p = 0.0014). However, salivary lysozyme, lactoferrin, human β-defensin-2, and LL-37 secretion rates did not change from baseline to after exercise in both trials.

Conclusion

These results suggest that salivary SIgA secretion may differ between acute CE and IE, whereas secretory responses to salivary anti-microbial peptides may not differ.