Scholarlink

Introduction <p>Neuromuscular electrical stimulation (NMES) is used as a rehabilitation technique for individuals with physical function limitations and mobility impairments. However, the potential for NMES-induced muscle contraction to improve metabolic health is unclear. This study investigated the effect of NMES on glycemic control and energy expenditure in a predominantly Hispanic population.</p> Methods <p>Overweight/obese participants with hyperglycemia (<i>N</i> = 56 [Males: 19; Females: 37] Age: 33.3 ± 11.8&#xa0;years; BMI: 34.8 ± 5.6&#xa0;kg/m<sup>2</sup>) underwent 30&#xa0;min of NMES on both quadriceps muscles after an overnight fast. Glucose levels were continuously measured for over 48&#xa0;h, encompassing the stimulation day and a control day, using a continuous glucose monitor. Standardized eucaloric diet was provided on both days. Energy expenditure and substrate utilization were measured by indirect calorimetry before and during the NMES application.</p> Results <p>Thirty minutes of NMES treatment reduced glucose levels compared to baseline glucose (116.2 ± 2.7&#xa0;mg/dL to 113.2 ± 2.5&#xa0;mg/dL; <i>p</i> &lt; 0.0001). Glycemic control determined by 24-h glucose variability/fluctuations was significantly lower on the day of NMES compared to the control day (18.0 ± 1.0&#xa0;mg/dL vs 20.0 ± 1.2&#xa0;mg/dL; <i>p</i> &lt; 0.05). Energy expenditure (18.8 ± 0.3&#xa0;kcal.Day<sup>−1</sup>.Kg<sup>−1</sup> to 19.0 ± 0.3&#xa0;kcal.Day<sup>−1</sup>.Kg<sup>−1</sup>; <i>p</i> &lt; 0.05) and respiratory exchange ratio (0.79 ± 0.01 to 0.80 ± 0.01; <i>p</i> &lt; 0.05) increased during stimulation compared to the baseline.</p> Conclusion <p>Acute application of NMES results in improvement in glycemic control and energy expenditure in the short term. Future studies are needed to determine if chronic NMES-induced muscle contraction can provide an alternate strategy to manage hyperglycemia.</p> Clinical trial registration <p>NCT03947697 May 2019.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Neuromuscular electrical stimulation enhances glycemic control and carbohydrate utilization in sedentary, predominantly Hispanic overweight or obese individuals with hyperglycemia

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月28日

查看全文
  • Jehu N. Apaflo,
  • Gabriel Narvaez,
  • Irene John Tomy,
  • Ali Mossayebi,
  • Zahra Fatahimeiabadi,
  • Andrew J. McAinch,
  • John P. Thyfault,
  • Kisuk Min,
  • Hyejin Jung,
  • Amy E. Wagler,
  • Sudip Bajpeyi

摘要

Introduction

Neuromuscular electrical stimulation (NMES) is used as a rehabilitation technique for individuals with physical function limitations and mobility impairments. However, the potential for NMES-induced muscle contraction to improve metabolic health is unclear. This study investigated the effect of NMES on glycemic control and energy expenditure in a predominantly Hispanic population.

Methods

Overweight/obese participants with hyperglycemia (N = 56 [Males: 19; Females: 37] Age: 33.3 ± 11.8 years; BMI: 34.8 ± 5.6 kg/m2) underwent 30 min of NMES on both quadriceps muscles after an overnight fast. Glucose levels were continuously measured for over 48 h, encompassing the stimulation day and a control day, using a continuous glucose monitor. Standardized eucaloric diet was provided on both days. Energy expenditure and substrate utilization were measured by indirect calorimetry before and during the NMES application.

Results

Thirty minutes of NMES treatment reduced glucose levels compared to baseline glucose (116.2 ± 2.7 mg/dL to 113.2 ± 2.5 mg/dL; p < 0.0001). Glycemic control determined by 24-h glucose variability/fluctuations was significantly lower on the day of NMES compared to the control day (18.0 ± 1.0 mg/dL vs 20.0 ± 1.2 mg/dL; p < 0.05). Energy expenditure (18.8 ± 0.3 kcal.Day−1.Kg−1 to 19.0 ± 0.3 kcal.Day−1.Kg−1; p < 0.05) and respiratory exchange ratio (0.79 ± 0.01 to 0.80 ± 0.01; p < 0.05) increased during stimulation compared to the baseline.

Conclusion

Acute application of NMES results in improvement in glycemic control and energy expenditure in the short term. Future studies are needed to determine if chronic NMES-induced muscle contraction can provide an alternate strategy to manage hyperglycemia.

Clinical trial registration

NCT03947697 May 2019.