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Aim <p>To evaluate whether a sustained period of normobaric O<sub>2</sub> breathing would modulate acral-skin vasoreactivity and thermosensitivity to localised cooling.</p> Methods <p>Eight healthy men performed a 30-min normoxic and hyperoxic (100% O<sub>2</sub>) hand cold (8&#xa0;°C water) provocation, while immersed to the chest either in 35.1 (0.4)°C (normothermic trial) or in 21.0 (0.1)°C (hypothermic trial) water. Finger temperature, circulatory and perceptual responses were monitored.</p> Results <p>During the normothermic trial, hyperoxia augmented the cold-induced drop in finger temperature, and attenuated the rewarming (<i>P</i> = 0.03). Hyperoxia also enhanced the sensation of pain (<i>P</i> = 0.04). During the hypothermic trial, hyperoxia did not modify finger temperature, circulatory and perceptual responses to cold (<i>P</i> &gt; 0.05).</p> Conclusion <p>In normothermia, hyperoxia aggravates finger cold-induced vasoconstriction and pain sensation. In mild hypothermia, however, any hyperoxia-evoked influence on finger vasomotion and thermonociception is overridden by the generalised vasoconstriction and thermal discomfort instigated by whole-body cooling.</p>

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Impact of normobaric hyperoxia on finger vasomotor and thermoperceptual responses to local cold in normothermic and mildly hypothermic individuals

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月29日

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  • Michail E. Keramidas,
  • Heather M. Bowes,
  • Maaike I. Moes,
  • Ola Eiken,
  • Mikael Gennser

摘要

Aim

To evaluate whether a sustained period of normobaric O2 breathing would modulate acral-skin vasoreactivity and thermosensitivity to localised cooling.

Methods

Eight healthy men performed a 30-min normoxic and hyperoxic (100% O2) hand cold (8 °C water) provocation, while immersed to the chest either in 35.1 (0.4)°C (normothermic trial) or in 21.0 (0.1)°C (hypothermic trial) water. Finger temperature, circulatory and perceptual responses were monitored.

Results

During the normothermic trial, hyperoxia augmented the cold-induced drop in finger temperature, and attenuated the rewarming (P = 0.03). Hyperoxia also enhanced the sensation of pain (P = 0.04). During the hypothermic trial, hyperoxia did not modify finger temperature, circulatory and perceptual responses to cold (P > 0.05).

Conclusion

In normothermia, hyperoxia aggravates finger cold-induced vasoconstriction and pain sensation. In mild hypothermia, however, any hyperoxia-evoked influence on finger vasomotion and thermonociception is overridden by the generalised vasoconstriction and thermal discomfort instigated by whole-body cooling.