Purpose This study investigated elite German athletes to (1) assess their serum 25(OH)D levels and the prevalence of insufficiency, (2) identify key factors influencing serum 25(OH)D levels, and (3) analyze the association between serum 25(OH)D levels and handgrip strength. Methods In this cross-sectional study, a total of 474 athletes (231 female), aged 13–39 years (mean 19.3 years), from ten Olympic disciplines were included. Serum 25(OH)D levels were analyzed via liquid chromatography–mass spectrometry, and 17 single nucleotide polymorphisms (SNPs) related to vitamin D metabolism were determined using leukocyte DNA. Grip strength was measured unimanually using a hand-held dynamometer. Multiple linear regressions were used to analyze the influence of SNPs, age, sex, season (summer vs. winter), and discipline (indoor vs. outdoor) on 25(OH)D status. Linear regression analyzed the relationship between handgrip strength and serum 25(OH)D levels. Results In total, 55.5% (n = 263) of athletes demonstrated insufficient serum 25(OH)D levels (< 30 ng/mL, < 75 nmol/L), with 16% (n = 76) showing levels below 20 ng/mL (50 nmol/L). After correction for multiple testing, significant influences on 25(OH)D levels were observed for the C allele of VDBP rs7041 (AC Genotype: <InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="421_2024_5699_Article_IEq1.gif" Format="GIF" Height="22" Rendition="HTML" Resolution="72" Type="Linedraw" Width="13" /> </InlineMediaObject> <EquationSource Format="TEX">$\widehat{\upbeta }$</EquationSource> <EquationSource Format="MATHML"><math> <mover accent="true"> <mi mathvariant="normal">β</mi> <mo stretchy="true">^</mo> </mover> </math></EquationSource> </InlineEquation> = 7.46, p < .001; CC Genotype: <InlineEquation ID="IEq2"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="421_2024_5699_Article_IEq1.gif" Format="GIF" Height="22" Rendition="HTML" Resolution="72" Type="Linedraw" Width="13" /> </InlineMediaObject> <EquationSource Format="TEX">$\widehat{\upbeta }$</EquationSource> <EquationSource Format="MATHML"><math> <mover accent="true"> <mi mathvariant="normal">β</mi> <mo stretchy="true">^</mo> </mover> </math></EquationSource> </InlineEquation> = 6.23, p = .001). Age (all p < .01) and discipline (indoor vs. outdoor; all p < .05) also influenced serum 25(OH)D levels. Furthermore, serum 25(OH)D was positively associated with handgrip strength (<InlineEquation ID="IEq3"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="421_2024_5699_Article_IEq1.gif" Format="GIF" Height="22" Rendition="HTML" Resolution="72" Type="Linedraw" Width="13" /> </InlineMediaObject> <EquationSource Format="TEX">$\widehat{\upbeta }$</EquationSource> <EquationSource Format="MATHML"><math> <mover accent="true"> <mi mathvariant="normal">β</mi> <mo stretchy="true">^</mo> </mover> </math></EquationSource> </InlineEquation>= 0.01, p < .001). Conclusion A high prevalence of insufficient 25(OH)D levels (< 30 ng/mL, < 75 nmol/L) was observed. We identified certain genetic variants as well as age and discipline as predictors of serum 25(OH)D levels. This knowledge may guide individualized diagnostic, nutritional, and supplementation strategies.

Vitamin D status and its determinants in German elite athletes

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2025年1月4日

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Sebastian Hacker,
Claudia Lenz,
Lukas Reichert,
Robert Ringseis,
Karen Zentgraf,
Karsten Krüger

摘要

Purpose

This study investigated elite German athletes to (1) assess their serum 25(OH)D levels and the prevalence of insufficiency, (2) identify key factors influencing serum 25(OH)D levels, and (3) analyze the association between serum 25(OH)D levels and handgrip strength.

Methods

In this cross-sectional study, a total of 474 athletes (231 female), aged 13–39 years (mean 19.3 years), from ten Olympic disciplines were included. Serum 25(OH)D levels were analyzed via liquid chromatography–mass spectrometry, and 17 single nucleotide polymorphisms (SNPs) related to vitamin D metabolism were determined using leukocyte DNA. Grip strength was measured unimanually using a hand-held dynamometer. Multiple linear regressions were used to analyze the influence of SNPs, age, sex, season (summer vs. winter), and discipline (indoor vs. outdoor) on 25(OH)D status. Linear regression analyzed the relationship between handgrip strength and serum 25(OH)D levels.

Results

In total, 55.5% (n = 263) of athletes demonstrated insufficient serum 25(OH)D levels (< 30 ng/mL, < 75 nmol/L), with 16% (n = 76) showing levels below 20 ng/mL (50 nmol/L). After correction for multiple testing, significant influences on 25(OH)D levels were observed for the C allele of VDBP rs7041 (AC Genotype: $\widehat{\upbeta }$ $\hat{β}$ = 7.46, p < .001; CC Genotype: $\widehat{\upbeta }$ $\hat{β}$ = 6.23, p = .001). Age (all p < .01) and discipline (indoor vs. outdoor; all p < .05) also influenced serum 25(OH)D levels. Furthermore, serum 25(OH)D was positively associated with handgrip strength ( $\widehat{\upbeta }$ $\hat{β}$ = 0.01, p < .001).

Conclusion

A high prevalence of insufficient 25(OH)D levels (< 30 ng/mL, < 75 nmol/L) was observed. We identified certain genetic variants as well as age and discipline as predictors of serum 25(OH)D levels. This knowledge may guide individualized diagnostic, nutritional, and supplementation strategies.