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Purpose <p>The aim of this study was to investigate the influence of prolonged aerobic exercise on cardiac, muscular and renal inflammatory markers in a group of trained obese men.</p> Methods <p>Seventeen men (aged 40 ± 6&#xa0;years; body mass index [BMI] 31.3 ± 2.8&#xa0;kg&#xa0;m<sup>−2</sup>, maximal oxygen uptake [V’O<sub>2</sub>max] 41.5 ± 5.6&#xa0;ml&#xa0;kg<sup>−1</sup>&#xa0;min<sup>−1</sup>) ran a half, 30&#xa0;km, or full marathon. Troponin I (cTnI), the n-terminal creatine kinase-myocardial band (CK-MB), pro b-type natriuretic peptide (NT-proBNP), lactate dehydrogenase (LDH), myoglobin, creatinine (CREA) and the estimated glomerular filtration rate (eGFR)&#xa0;were measured before (T0), immediately after (T1) and 3&#xa0;days after the race (T2).</p> Results <p>The concentrations of cTnI, myoglobin, LDH, CK-MB and CREA significantly increased (<i>P</i> &lt; 0.05), whereas eGRF decreased at T1 (<i>P</i> &lt; 0.05). All the above parameters returned to baseline at T2, except for eGFR, which remained lower than that at T0 (<i>P</i> &lt; 0.05). A positive association was observed between ΔCK-MB (%) and the time spent in Zone 3 during the race (<i>R</i> = 0.686, <i>P</i> = 0.014). The Δmyoglobin (%) was positively correlated with race time, race mean speed and time in Zone 3 (<i>R</i> = 0.574–0.862, <i>P</i> &lt; 0.05). The ∆CREA values were moderately correlated with the race mean HR<sub>MAX</sub> (%) and time spent in Zone 3 (%) (<i>R</i> = 0.514–0.610; <i>P</i> = 0.05). The ∆eGRF values were moderately inversely correlated with the time spent in Zone 3 (%) (<i>R</i> =  – 0.627; <i>P</i> &lt; 0.05).</p> Conclusion <p>Changes in cardiac, muscular and renal inflammatory markers in trained men with obesity are consistent with those described in the literature in normal-weight individuals. Finally, running parameters, such as running time, average running intensity and time in Zone 3 appear to be responsible for the changes in cardiac, muscular and renal function markers after long-distance running.</p>

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The influence of prolonged aerobic exercise on cardiac, muscular, and renal biomarkers in trained individuals with obesity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月9日

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  • M. D’Alleva,
  • J. M. Sanz,
  • N. Giovanelli,
  • F. Graniero,
  • L. Mari,
  • R. Spaggiari,
  • D. Sergi,
  • S. Ghisellini,
  • A. Passaro,
  • S. Lazzer

摘要

Purpose

The aim of this study was to investigate the influence of prolonged aerobic exercise on cardiac, muscular and renal inflammatory markers in a group of trained obese men.

Methods

Seventeen men (aged 40 ± 6 years; body mass index [BMI] 31.3 ± 2.8 kg m−2, maximal oxygen uptake [V’O2max] 41.5 ± 5.6 ml kg−1 min−1) ran a half, 30 km, or full marathon. Troponin I (cTnI), the n-terminal creatine kinase-myocardial band (CK-MB), pro b-type natriuretic peptide (NT-proBNP), lactate dehydrogenase (LDH), myoglobin, creatinine (CREA) and the estimated glomerular filtration rate (eGFR) were measured before (T0), immediately after (T1) and 3 days after the race (T2).

Results

The concentrations of cTnI, myoglobin, LDH, CK-MB and CREA significantly increased (P < 0.05), whereas eGRF decreased at T1 (P < 0.05). All the above parameters returned to baseline at T2, except for eGFR, which remained lower than that at T0 (P < 0.05). A positive association was observed between ΔCK-MB (%) and the time spent in Zone 3 during the race (R = 0.686, P = 0.014). The Δmyoglobin (%) was positively correlated with race time, race mean speed and time in Zone 3 (R = 0.574–0.862, P < 0.05). The ∆CREA values were moderately correlated with the race mean HRMAX (%) and time spent in Zone 3 (%) (R = 0.514–0.610; P = 0.05). The ∆eGRF values were moderately inversely correlated with the time spent in Zone 3 (%) (R =  – 0.627; P < 0.05).

Conclusion

Changes in cardiac, muscular and renal inflammatory markers in trained men with obesity are consistent with those described in the literature in normal-weight individuals. Finally, running parameters, such as running time, average running intensity and time in Zone 3 appear to be responsible for the changes in cardiac, muscular and renal function markers after long-distance running.