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Objective <p>This study aimed to clarify the relationship between the night shift work and hypertensive disorders of pregnancy (HDP). Moreover, we examined whether night shift work is associated with early-onset or late-onset HDP.</p> Methods <p>This nationwide prospective cohort study analyzed the data of 104,043 fetuses and their mother records from the Japan Environment and Children’s Study. After excluding participants with multiple gestations, preconception hypertension, and insufficient data, 90,660 mother–child dyads were included for analysis. Night shift work was assessed using a second/third trimester questionnaire and defined as working one or more shifts per month during hours other than typical daytime work. Multiple logistic regression analysis was conducted to estimate the association between night shift work and HDP.</p> Results <p>The overall incidence rate of HDP, early-onset HDP, and late-onset HDP were 2.5% (2,282/90,660), 0.5% (487/90,660), and 2.0% (1,795/90,660), respectively. After adjusting for potential confounding factors, the risk of HDP was significantly higher in the night shift work group (adjusted OR [aOR], 1.20; 95% CI 1.01–1.44; <i>p</i> = 0.04). However, no significant association was found between night shift work and the incidence of early-onset HDP (aOR, 1.09; 95% CI 0.72–1.66; <i>p</i> = 0.68). In contrast, after adjusting for potential confounding factors, the risk of late-onset HDP was significantly higher in the night shift work group (aOR, 1.23; 95% CI 1.01–1.49; <i>p</i> = 0.04).</p> Conclusion <p>Night-shift work during pregnancy may be associated with an increased risk of HDP, particularly late-onset HDP.</p>

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Night shift work as a potential risk factor for hypertensive disorders of pregnancy: the Japan environment and children’s study

  • 期刊论文

  • 发表日期：

    2026年7月11日

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  • Satoshi Shinohara,
  • Reiji Kojima,
  • Sanae Otawa,
  • Megumi Kushima,
  • Kunio Miyake,
  • Hideki Yui,
  • Tadao Ooka,
  • Hiroshi Yokomichi,
  • Zentaro Yamagata,
  • Ryoji Shinohara

摘要

Objective

This study aimed to clarify the relationship between the night shift work and hypertensive disorders of pregnancy (HDP). Moreover, we examined whether night shift work is associated with early-onset or late-onset HDP.

Methods

This nationwide prospective cohort study analyzed the data of 104,043 fetuses and their mother records from the Japan Environment and Children’s Study. After excluding participants with multiple gestations, preconception hypertension, and insufficient data, 90,660 mother–child dyads were included for analysis. Night shift work was assessed using a second/third trimester questionnaire and defined as working one or more shifts per month during hours other than typical daytime work. Multiple logistic regression analysis was conducted to estimate the association between night shift work and HDP.

Results

The overall incidence rate of HDP, early-onset HDP, and late-onset HDP were 2.5% (2,282/90,660), 0.5% (487/90,660), and 2.0% (1,795/90,660), respectively. After adjusting for potential confounding factors, the risk of HDP was significantly higher in the night shift work group (adjusted OR [aOR], 1.20; 95% CI 1.01–1.44; p = 0.04). However, no significant association was found between night shift work and the incidence of early-onset HDP (aOR, 1.09; 95% CI 0.72–1.66; p = 0.68). In contrast, after adjusting for potential confounding factors, the risk of late-onset HDP was significantly higher in the night shift work group (aOR, 1.23; 95% CI 1.01–1.49; p = 0.04).

Conclusion

Night-shift work during pregnancy may be associated with an increased risk of HDP, particularly late-onset HDP.