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<p>Eosinophils are increasingly recognized as contributors to tissue remodeling and chronic inflammation, yet their spatiotemporal behavior in sterile granulomatous reactions is incompletely defined. We performed a day&#xa0;1–14&#xa0;histopathological time course of a reproducible sterile granuloma induced by implantation of a heat-coagulated egg white pellet into the murine peritoneum. The reaction showed a biphasic inflammatory pattern with early neutrophil predominance followed by a sustained eosinophil-rich phase that persisted through late remodeling. Across time points, lesions progressed from exudative inflammation with prominent fibrin to organized fibroplasia and neovascularization, culminating in collagen-dominated encapsulation by day&#xa0;14. Eosinophils concentrated at the pellet–tissue interface, frequently displaying apoptosis and degranulation, and occurring in close spatial association with fibroblasts and macrophages. At late time points, the outer granuloma zone contained mononuclear phagocyte/macrophage-like cells alongside dense connective tissue maturation. Together, these findings provide a temporal histopathology atlas of sterile implant granuloma maturation and introduce a semiquantitative framework that summarizes key tissue-composition transitions (fibrinous exudate → fibroplasia/collagen encapsulation) alongside eosinophil enrichment at the pellet–tissue interface.</p>

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Eosinophil-associated matrix remodeling in a sterile granulomatous inflammation model: a temporal histopathological analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月25日

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  • Bruno Marques Vieira,
  • Milla Bezerra Paiva,
  • Juliane Siqueira Francisco,
  • Rebeca Sousa Brum,
  • Lucas Everton Simões,
  • Maria Ignez Capella Gaspar-Elsas,
  • Pedro Xavier-Elsas

摘要

Eosinophils are increasingly recognized as contributors to tissue remodeling and chronic inflammation, yet their spatiotemporal behavior in sterile granulomatous reactions is incompletely defined. We performed a day 1–14 histopathological time course of a reproducible sterile granuloma induced by implantation of a heat-coagulated egg white pellet into the murine peritoneum. The reaction showed a biphasic inflammatory pattern with early neutrophil predominance followed by a sustained eosinophil-rich phase that persisted through late remodeling. Across time points, lesions progressed from exudative inflammation with prominent fibrin to organized fibroplasia and neovascularization, culminating in collagen-dominated encapsulation by day 14. Eosinophils concentrated at the pellet–tissue interface, frequently displaying apoptosis and degranulation, and occurring in close spatial association with fibroblasts and macrophages. At late time points, the outer granuloma zone contained mononuclear phagocyte/macrophage-like cells alongside dense connective tissue maturation. Together, these findings provide a temporal histopathology atlas of sterile implant granuloma maturation and introduce a semiquantitative framework that summarizes key tissue-composition transitions (fibrinous exudate → fibroplasia/collagen encapsulation) alongside eosinophil enrichment at the pellet–tissue interface.