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Purpose <p>To evaluate the 6-month clinical outcomes of 577-nm subthreshold micropulse laser treatment (SMPLT) in patients with chronic central serous chorioretinopathy (cCSCR) and to identify factors associated with complete resolution of subretinal fluid (CRSF).</p> Methods <p>This retrospective cross-sectional study included patients with cCSCR treated with 577-nm SMPLT using a 15% duty cycle. Best-corrected visual acuity (BCVA), central foveal thickness (CFT), subretinal fluid height (SRFH), subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI), and outer nuclear layer thickness (ONLT) were evaluated at baseline and at 1, 3, and 6 months after treatment. Factors influencing CRSF were analyzed.</p> Results <p>Thirty-five eyes of 35 patients were included. BCVA improved significantly at all follow-up visits compared with baseline (all <i>p</i> &lt; 0.001). CFT and SRFH decreased significantly at 1, 3, and 6 months after treatment (all <i>p</i> &lt; 0.001). SFCT showed significant reduction at 1 and 6 months (<i>p</i> = 0.001 and <i>p</i> = 0.018), whereas no significant changes were observed in CVI or ONLT. CRSF was achieved in 22.9% of eyes at 1 month, 48.6% at 3 months, and 60% at 6 months. Higher complete resolution rates were observed in eyes without retinal pigment epithelium (RPE) alterations (75% vs. 57.1%). Female sex was associated with lower complete resolution rates, while higher baseline CFT and SRFH and CVI were associated with CRSF.</p> Conclusions <p>577-nm SMPLT using a 15% duty cycle was associated with significant functional and anatomical improvement in cCSCR. Treatment before the development of RPE alterations may be associated with more favorable anatomical outcomes.</p>

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Clinical outcomes of 577-nm subthreshold micropulse laser therapy in chronic central serous chorioretinopathy: influence of retinal pigment epithelium alterations and baseline OCT characteristics

  • 期刊论文

  • 发表日期：

    2026年7月3日

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  • Kevser Koyuncu,
  • Zeynep Akkul,
  • Mahmut Oguz Ulusoy,
  • Ayna Sariyeva Ismayilov,
  • Cansu Erseven

摘要

Purpose

To evaluate the 6-month clinical outcomes of 577-nm subthreshold micropulse laser treatment (SMPLT) in patients with chronic central serous chorioretinopathy (cCSCR) and to identify factors associated with complete resolution of subretinal fluid (CRSF).

Methods

This retrospective cross-sectional study included patients with cCSCR treated with 577-nm SMPLT using a 15% duty cycle. Best-corrected visual acuity (BCVA), central foveal thickness (CFT), subretinal fluid height (SRFH), subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI), and outer nuclear layer thickness (ONLT) were evaluated at baseline and at 1, 3, and 6 months after treatment. Factors influencing CRSF were analyzed.

Results

Thirty-five eyes of 35 patients were included. BCVA improved significantly at all follow-up visits compared with baseline (all p < 0.001). CFT and SRFH decreased significantly at 1, 3, and 6 months after treatment (all p < 0.001). SFCT showed significant reduction at 1 and 6 months (p = 0.001 and p = 0.018), whereas no significant changes were observed in CVI or ONLT. CRSF was achieved in 22.9% of eyes at 1 month, 48.6% at 3 months, and 60% at 6 months. Higher complete resolution rates were observed in eyes without retinal pigment epithelium (RPE) alterations (75% vs. 57.1%). Female sex was associated with lower complete resolution rates, while higher baseline CFT and SRFH and CVI were associated with CRSF.

Conclusions

577-nm SMPLT using a 15% duty cycle was associated with significant functional and anatomical improvement in cCSCR. Treatment before the development of RPE alterations may be associated with more favorable anatomical outcomes.