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Purpose <p>To assess the risk of conversion of non-exudative macular neovascularisations (NEMNV) in relation to disease history in sustained unilateral neovascular age-related macular degeneration (AMD).</p> Methods <p>This exploratory case-only cohort study included six-monthly visits. Fellow-eye NEMNV were identified using fluorescein and indocyanine green angiography. Patients were stratified by time since first-eye exudation: &lt; 5&#xa0;years (G1) or ≥ 5&#xa0;years (G2). The primary outcome was the cumulative annual conversion rate of NEMNV, expressed as conversion rate ratios (CRR) with 95% confidence intervals (CI). Secondary outcomes were independent grading of foveal involvement, core vessel, central core vessel, round shape, sharp borders, and lesion growth.</p> Results <p>A total of 134 patients (65.7% female) were included. Mean age at baseline was 74.2&#xa0;years (SD 8.0). Median time since first-eye exudation was 2.9&#xa0;years (IQR 1.0–6.3). Patients in G2 had an earlier age at first-eye exudation (66.0 [9.1] years) than G1 (72.7 [7.8]; P &lt; .001). Seven NEMNV lesions were identified (G1:2, G2:5). Cumulative conversion rates were 22.1% overall, 14.3% in G1, and 27.1% in G2. CRR were 2.3 (95% CI 0.6–6.2), 1.3 (95% CI 0.0 – 7.8), and 4.0 (95% CI 0.7 – 16.8). All but one NEMNV showed growth.</p> Conclusion <p>In this limited sample, most NEMNV show growth time regardless of conversion to exudative AMD and appear at a higher risk of conversion. The rate of conversion varies with the age of onset of first-eye exudation. Evaluating potential predictive signs of conversion may benefit from incorporating disease history with vascular features.</p>

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Clinical course of non-exudative macular neovascularisations in sustained unilateral neovascular age-related macular degeneration

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月29日

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  • Francesco Cinque,
  • Sofie C. A. ten Brink,
  • Mahfam Shahabi,
  • Anita de Breuk,
  • Thomas. J. Heesterbeek,
  • Caroline C. W. Klaver,
  • Carel B. Hoyng,
  • Yara T. E. Lechanteur

摘要

Purpose

To assess the risk of conversion of non-exudative macular neovascularisations (NEMNV) in relation to disease history in sustained unilateral neovascular age-related macular degeneration (AMD).

Methods

This exploratory case-only cohort study included six-monthly visits. Fellow-eye NEMNV were identified using fluorescein and indocyanine green angiography. Patients were stratified by time since first-eye exudation: < 5 years (G1) or ≥ 5 years (G2). The primary outcome was the cumulative annual conversion rate of NEMNV, expressed as conversion rate ratios (CRR) with 95% confidence intervals (CI). Secondary outcomes were independent grading of foveal involvement, core vessel, central core vessel, round shape, sharp borders, and lesion growth.

Results

A total of 134 patients (65.7% female) were included. Mean age at baseline was 74.2 years (SD 8.0). Median time since first-eye exudation was 2.9 years (IQR 1.0–6.3). Patients in G2 had an earlier age at first-eye exudation (66.0 [9.1] years) than G1 (72.7 [7.8]; P < .001). Seven NEMNV lesions were identified (G1:2, G2:5). Cumulative conversion rates were 22.1% overall, 14.3% in G1, and 27.1% in G2. CRR were 2.3 (95% CI 0.6–6.2), 1.3 (95% CI 0.0 – 7.8), and 4.0 (95% CI 0.7 – 16.8). All but one NEMNV showed growth.

Conclusion

In this limited sample, most NEMNV show growth time regardless of conversion to exudative AMD and appear at a higher risk of conversion. The rate of conversion varies with the age of onset of first-eye exudation. Evaluating potential predictive signs of conversion may benefit from incorporating disease history with vascular features.