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Purpose <p>This study aims to evaluate the association of optic cup-to-disc ratio (CDR) with magnification-adjusted optical coherence tomography (OCT) peripapillary retinal nerve fibre layer (RNFL) and macula ganglion cell complex (GCC) thickness in Asian myopic children, to help clinicians better evaluate glaucoma risk in myopic children with increased CDR.</p> Methods <p>In a prospective clinical cohort study, myopic children aged 7–16 years were assessed annually over 2 years, excluding children with overt glaucomatous changes. Right eye data including visual acuity, intraocular pressure, cycloplegic autorefraction, axial length, fundus photographs and magnification-adjusted OCT of the optic disc and macula were collected. Children were divided into three OCT-assessed vertical CDR (vCDR) subgroups (0.00-0.39, 0.40–0.59, and 0.60–0.90) for analyses.</p> Results <p>Among 901 eyes, 162 (18.2%) eyes had a vCDR <i>≥</i> 0.6. Multivariate analysis found that larger vCDR was associated with non-Chinese race, younger age, flatter corneas, decreased optic disc tilt, larger disc area with smaller disc rim, increased AL, sectoral RNFL thinning with nasal RNFL thickening, and reduced use of combined atropine-optical treatment. In 452 eyes with two-year follow-up data of sufficient quality, no change in OCT RNFL and GCC were noted over time. Interestingly, increased vCDR was associated with greater myopia progression.</p> Conclusion <p>In eyes with larger CDR, the presence of flatter corneas, larger optic disc area (e.g. &gt;2mm<sup>2</sup>), and stable OCT RNFL and GCC thickness over time are reassuring for a non-glaucomatous state. However, given the increased risk of myopia progression, closer myopia monitoring and management may be necessary.</p>

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Optical coherence tomography characteristics in myopic children with large cup-disc ratios

  • 期刊论文

  • 发表日期：

    2026年4月25日

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  • Mark Kit Lim,
  • Rachel Shujuan Chong,
  • Muna Al Ajmi,
  • Hla Myint Htoon,
  • Audrey Chia

摘要

Purpose

This study aims to evaluate the association of optic cup-to-disc ratio (CDR) with magnification-adjusted optical coherence tomography (OCT) peripapillary retinal nerve fibre layer (RNFL) and macula ganglion cell complex (GCC) thickness in Asian myopic children, to help clinicians better evaluate glaucoma risk in myopic children with increased CDR.

Methods

In a prospective clinical cohort study, myopic children aged 7–16 years were assessed annually over 2 years, excluding children with overt glaucomatous changes. Right eye data including visual acuity, intraocular pressure, cycloplegic autorefraction, axial length, fundus photographs and magnification-adjusted OCT of the optic disc and macula were collected. Children were divided into three OCT-assessed vertical CDR (vCDR) subgroups (0.00-0.39, 0.40–0.59, and 0.60–0.90) for analyses.

Results

Among 901 eyes, 162 (18.2%) eyes had a vCDR ≥ 0.6. Multivariate analysis found that larger vCDR was associated with non-Chinese race, younger age, flatter corneas, decreased optic disc tilt, larger disc area with smaller disc rim, increased AL, sectoral RNFL thinning with nasal RNFL thickening, and reduced use of combined atropine-optical treatment. In 452 eyes with two-year follow-up data of sufficient quality, no change in OCT RNFL and GCC were noted over time. Interestingly, increased vCDR was associated with greater myopia progression.

Conclusion

In eyes with larger CDR, the presence of flatter corneas, larger optic disc area (e.g. >2mm2), and stable OCT RNFL and GCC thickness over time are reassuring for a non-glaucomatous state. However, given the increased risk of myopia progression, closer myopia monitoring and management may be necessary.