Purpose <p>To compare systemic inflammation parameters and blood lipid profile in patients with conjunctivochalasis versus healthy individuals.</p> Methods <p>Thirty patients with conjunctivochalasis(Cch) and thirty age-matched healthy controls were included in this retrospective study. Complete blood count (CBC) parameters and serum levels of total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG) were obtained from electronic medical records. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-HDL ratio (MHR) were calculated for each participant. Group differences were analyzed statistically.</p> Results <p>The monocyte-to-HDL ratio was significantly higher in the conjunctivochalasis group (<i>p</i> = 0.023), while hemoglobin levels were significantly lower (<i>p</i> = 0.001). No additional significant differences were observed in other hematological or lipid parameters.</p> Conclusion <p>This study is the first to demonstrate an elevated monocyte-to-HDL ratio in patients with conjunctivochalasis. The concurrent reduction in hemoglobin levels provides further support for a potential systemic association. These findings suggest that conjunctivochalasis may involve not only localized ocular changes but also systemic inflammatory processes.</p>