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Background <p>Central serous chorioretinopathy (CSCR) is usually self-limiting but recurs in 30–50% of cases. This study compares demographic, clinical, and imaging data between patients with and without recurrent CSCR to identify predictors of recurrence.</p> Methods <p>Baseline and follow-up data were collected from 277 eyes of 265 patients with acute CSCR. Patients were divided into recurrent or non-recurrent CSCR groups based on recurrence within three months of resolution. OCT biomarkers analyzed included central macular thickness (CMT), double-layered sign (DLS), subfoveal choroidal thickness (SFCT), neurosensory retinal detachment height (NSRD), Haller layer thickness (HVT), inner choroidal thickness (ICT), and choroidal vascularity index (CVI).</p> Results <p>This study involved 265 patients with 277 eyes. The non-recurrent group comprised 157 patients (158 eyes), with 108 (119 eyes) in the recurrent group. Baseline mean CMT and ICT at follow-up were significantly greater in the non-recurrent group than in the recurrent group. Follow-up CMT and DLS heights were significantly greater in the recurrent group. Mean CVI was significantly greater in the non-recurrent group than the recurrent group at baseline and follow-up. In a multivariate logistic regression model, hypertension was significantly negatively associated with non-recurrent CSCR (OR = 0.449, 95% CI: 0.236–0.855, <i>p</i> = 0.015).</p> Conclusion <p>The non-recurrent group had significantly increased CMT at baseline but significantly decreased CMT and DLS height at follow-up. ICT was greater in the non-recurrent group compared to recurrent counterparts at follow-up. Mean CVI was greater in the non-recurrent group at both time points. Hypertension may be associated with disease recurrence.</p>

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Choroidal imaging biomarkers as predictors of recurrent central serous chorioretinopathy: A multicenter retrospective study – MICRoN report number five

  • 期刊论文

  • 发表日期：

    2026年2月17日

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  • Arman Zarnegar,
  • Nasiq Hasan,
  • Sumit Randhir Singh,
  • Adarsh Gadari,
  • Korrina Gidwani,
  • Elizabeth J. Rossin,
  • Charles C. Wykoff,
  • Samer Khateb,
  • Rahul N. Khurana,
  • Zachary Kroeger,
  • Stela Vujosevic,
  • Maurizio Battaglia Parodi,
  • Peranut Chotcomwongse,
  • Paisan Ruamviboonsuk,
  • Kiran K. Vupparaboina,
  • Lihteh Wu,
  • Jay Chhablani,
  • Nasiq Hasan,
  • Arman Zarnegar,
  • Carmen Antia,
  • Luis Aria Barquet,
  • Jessica Cao,
  • Lisa Checchin,
  • Peranut Chotcomwongse,
  • Lorenzo Ferro Desideri,
  • Adrain Fung,
  • Manjot Gill,
  • Felicia Hertkorn,
  • Samer Khateb,
  • Rahul N. Khurana,
  • Min Kim,
  • Yusuf Ashfaq,
  • Zachary Kroeger,
  • Timothy Lai,
  • Luiz Lima,
  • Marion R. Munk,
  • Lorenzo Pili,
  • Maurizio Battaglia Parodi,
  • Gabriele Piccoli,
  • Francisco Rodriguez,
  • Priya Shah,
  • Panisa Singhanetr,
  • Elizabeth Rossin,
  • Paisan Ruamviboonsuk,
  • Stanley Saju,
  • Ninan Jacob,
  • Niroj Kumar Sahoo,
  • Rufino Silva,
  • Kent Small,
  • Carol Villafeurte,
  • Stela Vujosevic,
  • Lucia Sobrin,
  • Jay Wang,
  • Halit Winter,
  • Lihteh Wu,
  • Charles Wykoff,
  • Glenn Yiu,
  • Micheal Zhang,
  • Bita Momenaei,
  • Roselind Ni,
  • Sunir Garg,
  • Giulia Gregori,
  • Marco Lupidi,
  • Andrea Corletti,
  • Elodie Bousquet,
  • Naoya Imanaga,
  • Hideki Koizumi,
  • Jay Chhablani

摘要

Background

Central serous chorioretinopathy (CSCR) is usually self-limiting but recurs in 30–50% of cases. This study compares demographic, clinical, and imaging data between patients with and without recurrent CSCR to identify predictors of recurrence.

Methods

Baseline and follow-up data were collected from 277 eyes of 265 patients with acute CSCR. Patients were divided into recurrent or non-recurrent CSCR groups based on recurrence within three months of resolution. OCT biomarkers analyzed included central macular thickness (CMT), double-layered sign (DLS), subfoveal choroidal thickness (SFCT), neurosensory retinal detachment height (NSRD), Haller layer thickness (HVT), inner choroidal thickness (ICT), and choroidal vascularity index (CVI).

Results

This study involved 265 patients with 277 eyes. The non-recurrent group comprised 157 patients (158 eyes), with 108 (119 eyes) in the recurrent group. Baseline mean CMT and ICT at follow-up were significantly greater in the non-recurrent group than in the recurrent group. Follow-up CMT and DLS heights were significantly greater in the recurrent group. Mean CVI was significantly greater in the non-recurrent group than the recurrent group at baseline and follow-up. In a multivariate logistic regression model, hypertension was significantly negatively associated with non-recurrent CSCR (OR = 0.449, 95% CI: 0.236–0.855, p = 0.015).

Conclusion

The non-recurrent group had significantly increased CMT at baseline but significantly decreased CMT and DLS height at follow-up. ICT was greater in the non-recurrent group compared to recurrent counterparts at follow-up. Mean CVI was greater in the non-recurrent group at both time points. Hypertension may be associated with disease recurrence.