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Purpose <p>While central serous chorioretinopathy (CSCR) frequently resolves after the first episode, in 30–50% of cases, subretinal fluid (SRF) persists and can substantially impair vision. To identify persistence predictors, this study compared demographic, clinical, and imaging data between patients with resolution and SRF persistence.</p> Methods <p>Retrospective data were collected at baseline and follow-up from 308 eyes of 295 patients with CSCR in collaboration with the Macula Society CSCR Study Group. Patients were divided into a resolved (RG) and a persistent CSCR group (PG). Patients with known recurrence after resolution were excluded. Optical coherence tomography (OCT) biomarkers including central macular thickness (CMT), subfoveal choroidal thickness (SFCT), neurosensory detachment height (NSD), Haller layer thickness, inner choroidal thickness (ICT), and choroidal vascularity index (CVI) were analysed.</p> Results <p>PG had 148 eyes and RG had 160 eyes. Mean age in PG vs RG was 47.62 ± 11.63 vs. 44.89 ± 10.12&#xa0;years (<i>p</i> = 0.029). Mean presenting symptom duration was significantly greater in PG than RG (8.67 ± 23.33 vs. 4.33 ± 31.18&#xa0;months) (<i>p</i> = 0.005). There was a higher frequency of complex cases (21.6%) in PG (<i>p</i> &lt; 0.001). Baseline mean CMT (358.11 ± 157.02&#xa0;microns) and NSD height (175.78 ± 134.34 microns) were significantly lower in PG (<i>p</i> = 0.007). Multivariate logistic regression analysis showed that each additional year of age was associated with a 22.3% increase in the odds of having persistent SRF.</p> Conclusion <p>Age at presentation, symptom duration, baseline CMT and NSD height may serve as practical risk stratifiers to identify eyes at high risk for chronicity in CSCR.</p> Key messages <p><Emphasis Type="BoldItalic">What is known</Emphasis></p> <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Delayed presentation and absence of early therapy predispose eyes to chronic CSCR.</p> </ItemContent> <ItemContent> <p>SFCT plays a predictive role in persistent CSCR.</p> </ItemContent> </UnorderedList></p> <p><Emphasis Type="BoldItalic">What is new</Emphasis></p> <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Age at presentation is a significant predictor of persistent SRF.</p> </ItemContent> <ItemContent> <p>Baseline CMT and NSD height may serve as practical risk stratifiers to identify eyes at high risk for chronicity.</p> </ItemContent> </UnorderedList></p>

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Predictors of persistent central serous chorioretinopathy: a multicenter retrospective study – MICRoN report number four

  • 期刊论文

  • 发表日期：

    2025年10月11日

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  • Priyanka Gandhi,
  • Nasiq Hasan,
  • Korrina Gidwani,
  • Jonathan Yang,
  • Jessica Cao,
  • Stanley Saju,
  • Charles C. Wykoff,
  • Samer Khateb,
  • Min Kim,
  • Ninan Jacob,
  • Yusuf Ashfaq,
  • Zachary Kroeger,
  • Micheal Zhang,
  • Peranut Chotcomwongse,
  • Paisan Ruamviboonsuk,
  • Halit Winter,
  • Manjot Gill,
  • Luiz H. Lima,
  • Lihteh Wu,
  • Jay Chhablani,
  • Carmen Antia,
  • Luis Aria Barquet,
  • Elodie Bousquet,
  • Lisa Checchin,
  • Andrea Corletti,
  • Lorenzo Ferro Desideri,
  • Adrain Fung,
  • Adarsh Gadari,
  • Utkarsh Doshi,
  • Sunir Garg,
  • Giulia Gregori,
  • Felicia Hertkorn,
  • Naoya Imanaga,
  • Rahul N. Khurana,
  • Hideki Koizumi,
  • Timothy Lai,
  • Marco Lupidi,
  • Bita Momenaei,
  • Marion R. Munk,
  • Roselind Ni,
  • Maurizio Battaglia Parodi,
  • Gabriele Piccoli,
  • Lorenzo Pili,
  • Francisco Rodriguez,
  • Elizabeth Rossin,
  • Niroj Kumar Sahoo,
  • Priya Shah,
  • Rufino Silva,
  • Panisa Singhanetr,
  • Kent Small,
  • Lucia Sobrin,
  • Carol Villafeurte,
  • Stela Vujosevic,
  • Jay Wang,
  • Glenn Yiu,
  • Arman Zarnegar,
  • Kiran K. Vupparaboina

摘要

Purpose

While central serous chorioretinopathy (CSCR) frequently resolves after the first episode, in 30–50% of cases, subretinal fluid (SRF) persists and can substantially impair vision. To identify persistence predictors, this study compared demographic, clinical, and imaging data between patients with resolution and SRF persistence.

Methods

Retrospective data were collected at baseline and follow-up from 308 eyes of 295 patients with CSCR in collaboration with the Macula Society CSCR Study Group. Patients were divided into a resolved (RG) and a persistent CSCR group (PG). Patients with known recurrence after resolution were excluded. Optical coherence tomography (OCT) biomarkers including central macular thickness (CMT), subfoveal choroidal thickness (SFCT), neurosensory detachment height (NSD), Haller layer thickness, inner choroidal thickness (ICT), and choroidal vascularity index (CVI) were analysed.

Results

PG had 148 eyes and RG had 160 eyes. Mean age in PG vs RG was 47.62 ± 11.63 vs. 44.89 ± 10.12 years (p = 0.029). Mean presenting symptom duration was significantly greater in PG than RG (8.67 ± 23.33 vs. 4.33 ± 31.18 months) (p = 0.005). There was a higher frequency of complex cases (21.6%) in PG (p < 0.001). Baseline mean CMT (358.11 ± 157.02 microns) and NSD height (175.78 ± 134.34 microns) were significantly lower in PG (p = 0.007). Multivariate logistic regression analysis showed that each additional year of age was associated with a 22.3% increase in the odds of having persistent SRF.

Conclusion

Age at presentation, symptom duration, baseline CMT and NSD height may serve as practical risk stratifiers to identify eyes at high risk for chronicity in CSCR.

Key messages

What is known

Delayed presentation and absence of early therapy predispose eyes to chronic CSCR.

SFCT plays a predictive role in persistent CSCR.

What is new

Age at presentation is a significant predictor of persistent SRF.

Baseline CMT and NSD height may serve as practical risk stratifiers to identify eyes at high risk for chronicity.