Scholarlink

Background <p>Cerebellar posterior lobes regulate various cognitive functions, and their damage can result in Cerebellar Cognitive Affective Syndrome (CCAS). The validity of the CCAS Scale (CCAS-S), a reliable tool to diagnose CCAS, remains unexplored in multiple sclerosis (MS).</p> Objectives <p>To evaluate the performance of CCAS-S in patients with MS (pwMS) at clinical onset, and to assess MRI characteristics of pwMS with CCAS (CCAS+) compared with healthy controls (HC) and with pwMS classified by standard cognitive assessments as cognitively impaired (CI+) or cognitively normal (CI− CCAS−).</p> Methods <p>One-hundred three early pwMS underwent CCAS-S, Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS), and Delis-Kaplan Executive Function System Sorting Test (D-KEFS-ST), used to classify patients into CI− CCAS−, CI+, and CCAS+. Twenty HC and 66 patients also underwent MRI to obtain lesion and volumetric parameters, diffusion MRI metrics, and cerebellum-brain functional connectivity (FC) on resting-state functional MRI, which were compared between groups.</p> Results <p>CCAS-S identified 14 (14%) pwMS with CCAS who were not detected by BICAMS or D-KEFS-ST. CCAS+ patients showed more severe microstructural damage in cerebellar normal-appearing white matter (lower fractional anisotropy, <i>p</i> = 0.020), and increased cerebro-cerebellar FC (involving right-limbic, left-frontoparietal, and left-default mode networks, <i>p</i> &lt; 0.05) compared with other subjects.</p> Conclusions <p>Our findings suggest that CCAS-S may represent a useful complementary tool to standard cognitive assessments, enhancing sensitivity in detecting cognitive impairment in early MS. Compared to HC and other MS patients, pwMS with CCAS show severe microstructural cerebellar damage and increased brain–cerebellar connectivity, suggesting a possible role of the cerebellum in their cognitive dysfunction. Validation in larger cohorts is warranted.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The cerebellar cognitive affective syndrome scale in early multiple sclerosis

  • 期刊论文

  • 发表日期：

    2026年3月19日

查看全文
  • Alessandro Miscioscia,
  • Erica Silvestri,
  • Marco Puthenparampil,
  • Graziana Scialpi,
  • Angela Berardi,
  • Maria Colpo,
  • Giulia Vallini,
  • Mariagiulia Anglani,
  • Francesca Rinaldi,
  • Paola Perini,
  • Caterina Mainero,
  • Alessandra Bertoldo,
  • Paolo Gallo

摘要

Background

Cerebellar posterior lobes regulate various cognitive functions, and their damage can result in Cerebellar Cognitive Affective Syndrome (CCAS). The validity of the CCAS Scale (CCAS-S), a reliable tool to diagnose CCAS, remains unexplored in multiple sclerosis (MS).

Objectives

To evaluate the performance of CCAS-S in patients with MS (pwMS) at clinical onset, and to assess MRI characteristics of pwMS with CCAS (CCAS+) compared with healthy controls (HC) and with pwMS classified by standard cognitive assessments as cognitively impaired (CI+) or cognitively normal (CI− CCAS−).

Methods

One-hundred three early pwMS underwent CCAS-S, Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS), and Delis-Kaplan Executive Function System Sorting Test (D-KEFS-ST), used to classify patients into CI− CCAS−, CI+, and CCAS+. Twenty HC and 66 patients also underwent MRI to obtain lesion and volumetric parameters, diffusion MRI metrics, and cerebellum-brain functional connectivity (FC) on resting-state functional MRI, which were compared between groups.

Results

CCAS-S identified 14 (14%) pwMS with CCAS who were not detected by BICAMS or D-KEFS-ST. CCAS+ patients showed more severe microstructural damage in cerebellar normal-appearing white matter (lower fractional anisotropy, p = 0.020), and increased cerebro-cerebellar FC (involving right-limbic, left-frontoparietal, and left-default mode networks, p < 0.05) compared with other subjects.

Conclusions

Our findings suggest that CCAS-S may represent a useful complementary tool to standard cognitive assessments, enhancing sensitivity in detecting cognitive impairment in early MS. Compared to HC and other MS patients, pwMS with CCAS show severe microstructural cerebellar damage and increased brain–cerebellar connectivity, suggesting a possible role of the cerebellum in their cognitive dysfunction. Validation in larger cohorts is warranted.