Scholarlink

Background <p>Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are two synucleinopathies that share considerable overlap in their clinical and pathological characteristics.</p> Objective <p>This study aimed to evaluate the profile of phenotypic features across PDD and DLB to highlight their shared and distinctive features to explore any possible neurobiological underpinnings.</p> Methods <p>Patients diagnosed with Parkinson's disease dementia (PDD) (n=31) and dementia with Lewy bodies (DLB) (n=30) underwent evaluation for motor and non-motor symptoms using the International Parkinson and Movement Disorder Society -Unified Parkinson's Disease Rating Scale, the Scales for Outcomes in Parkinson’s Disease-Psychiatric Complications, the Montreal Cognitive Assessment, the Hospital Anxiety and Depression Scale and the Epworth Sleepiness Scale.</p> Results <p>Patients with PDD showed a more severe phenotype than those with DLB, with higher scores in motor severity, hallucinations, delusions, somnolence, and urinary dysfunction (all p≤0.01). The correlations between neuropsychiatric symptoms differed between groups. In both PDD and DLB, depression correlated with anxiety (PDD ρ=0.54; DLB ρ=0.65; both p&lt;0.001). In PDD, depression was additionally correlated with delusions (ρ=0.47; p&lt;0.001), apathy (ρ=0.41; p&lt;0.001), and sexual preoccupation (ρ=0.35; p&lt;0.001), whereas in DLB depression correlated with hallucinations (ρ=0.38; p&lt;0.001). PDD patients showed greater impairment in activities of daily living (ADLs) than DLB patients (p&lt;0.001), correlating with motor severity (ρ=0.65; p&lt;0.001) and fatigue (ρ=0.58; p&lt;0.001). In DLB, impaired ADLs were linked to hallucinations (ρ=0.39; p&lt;0.05), poorer cognition (ρ=0.47; p&lt;0.01), urinary dysfunction (ρ=0.38; p&lt;0.001), and fatigue (ρ=0.45; p&lt;0.001).</p> Conclusion <p>Despite being grouped under Lewy body dementias, these findings show PDD and DLB have distinct phenotypes reflecting their neurobiological underpinnings. This has implications for symptomatic and disease-modifying management. Future research should explore pathological mechanisms of these characteristics to improve diagnosis and treatment strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparing phenotypic features between Parkinson’s disease dementia and dementia with Lewy bodies

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月10日

查看全文
  • Chaminda Withanachchi Gunawardana,
  • Peter G. R. Burke,
  • Anna Ignatavicius,
  • Elie Matar,
  • Simon J. G. Lewis

摘要

Background

Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are two synucleinopathies that share considerable overlap in their clinical and pathological characteristics.

Objective

This study aimed to evaluate the profile of phenotypic features across PDD and DLB to highlight their shared and distinctive features to explore any possible neurobiological underpinnings.

Methods

Patients diagnosed with Parkinson's disease dementia (PDD) (n=31) and dementia with Lewy bodies (DLB) (n=30) underwent evaluation for motor and non-motor symptoms using the International Parkinson and Movement Disorder Society -Unified Parkinson's Disease Rating Scale, the Scales for Outcomes in Parkinson’s Disease-Psychiatric Complications, the Montreal Cognitive Assessment, the Hospital Anxiety and Depression Scale and the Epworth Sleepiness Scale.

Results

Patients with PDD showed a more severe phenotype than those with DLB, with higher scores in motor severity, hallucinations, delusions, somnolence, and urinary dysfunction (all p≤0.01). The correlations between neuropsychiatric symptoms differed between groups. In both PDD and DLB, depression correlated with anxiety (PDD ρ=0.54; DLB ρ=0.65; both p<0.001). In PDD, depression was additionally correlated with delusions (ρ=0.47; p<0.001), apathy (ρ=0.41; p<0.001), and sexual preoccupation (ρ=0.35; p<0.001), whereas in DLB depression correlated with hallucinations (ρ=0.38; p<0.001). PDD patients showed greater impairment in activities of daily living (ADLs) than DLB patients (p<0.001), correlating with motor severity (ρ=0.65; p<0.001) and fatigue (ρ=0.58; p<0.001). In DLB, impaired ADLs were linked to hallucinations (ρ=0.39; p<0.05), poorer cognition (ρ=0.47; p<0.01), urinary dysfunction (ρ=0.38; p<0.001), and fatigue (ρ=0.45; p<0.001).

Conclusion

Despite being grouped under Lewy body dementias, these findings show PDD and DLB have distinct phenotypes reflecting their neurobiological underpinnings. This has implications for symptomatic and disease-modifying management. Future research should explore pathological mechanisms of these characteristics to improve diagnosis and treatment strategies.