Scholarlink

<p>Parkinson's disease (PD) is the second most common neurodegenerative disease and the fastest-growing disability-causing neurological disorder worldwide. Based on the CPDR cohort from 19 clinical centers, we summarized the mortality information and characteristics of patients with PD, and analyzed the related factors affecting their survival. After a 6-year follow-up period, 562 of the 3,148 patients died, with a mortality rate of 3.03 deaths per 100 person-years, and a median survival time from disease onset of 23.33&#xa0;years. The most common cause of death was cardiovascular disease, followed by cerebrovascular disease and respiratory disease. Older age at onset, carriers of GBA1 gene variants, type 2 diabetes, higher LEDD, late H&amp;Y stage (especially H&amp;Y stage 4 and H&amp;Y stage 5), higher UPDRS part Ⅲ scores, a history of falls, depression, and cognitive dysfunction were associated with increased mortality. In contrast, undergoing deep brain stimulation (DBS) surgery and higher educational attainment was associated with a lower risk of death. Our findings contributed to further expanding the survival data of PD and advocated for early identification of high-risk patients for timely intervention to improve prognosis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Survival and related factors in patients with Parkinson's disease: a multicenter prospective cohort study in China

  • 期刊论文

  • 发表日期：

    2026年1月8日

查看全文
  • Tingwei Song,
  • Linghui Xiang,
  • Yuan Liu,
  • Hongxu Pan,
  • Yiting Wu,
  • Xiaoyun Li,
  • Fei Luo,
  • Chunyu Wang,
  • Lifang Lei,
  • Lingyan Yao,
  • Yuwen Zhao,
  • Zhenhua Liu,
  • Qiying Sun,
  • Jifeng Guo,
  • Beisha Tang,
  • Irene X. Y. Wu,
  • Li Yin,
  • Xiaoxia Zhou,
  • Qian Xu,
  • Beisha Tang,
  • Jifeng Guo,
  • Xinxiang Yan,
  • Qian Xu,
  • Zhenhua Liu,
  • Qiying Sun,
  • Chunyu Wang,
  • Lifang Lei,
  • Heng Wu,
  • Wei Huang,
  • Tao Wang,
  • Zheng Xue,
  • Puqing Wang,
  • Zhentao Zhang,
  • Ling Chen,
  • Qing Wang,
  • Yan Xu,
  • Oumei Cheng,
  • Yong You,
  • Yuhu Zhang,
  • Mei Yuan,
  • Guohua Zhao,
  • Shujian Li,
  • Xuejing Wang

摘要

Parkinson's disease (PD) is the second most common neurodegenerative disease and the fastest-growing disability-causing neurological disorder worldwide. Based on the CPDR cohort from 19 clinical centers, we summarized the mortality information and characteristics of patients with PD, and analyzed the related factors affecting their survival. After a 6-year follow-up period, 562 of the 3,148 patients died, with a mortality rate of 3.03 deaths per 100 person-years, and a median survival time from disease onset of 23.33 years. The most common cause of death was cardiovascular disease, followed by cerebrovascular disease and respiratory disease. Older age at onset, carriers of GBA1 gene variants, type 2 diabetes, higher LEDD, late H&Y stage (especially H&Y stage 4 and H&Y stage 5), higher UPDRS part Ⅲ scores, a history of falls, depression, and cognitive dysfunction were associated with increased mortality. In contrast, undergoing deep brain stimulation (DBS) surgery and higher educational attainment was associated with a lower risk of death. Our findings contributed to further expanding the survival data of PD and advocated for early identification of high-risk patients for timely intervention to improve prognosis.