Scholarlink

Introduction <p>Amygdala-predominant Lewy body (LB) pathology occurs frequently in association with advanced Alzheimer’s disease (AD). Its clinical significance is not yet fully clarified. We investigated the influence of amygdala-predominant LB in cognitive profiles and brain atrophy in the context of AD neuropathological change (ADNC).</p> Methods <p>We performed a retrospective cohort study from the National Alzheimer’s Coordinating Center dataset assessing the influence of amygdala-predominant LB and caudo-rostral LB stages in longitudinal neuropsychological and cognitive testing, as well as on regional brain volume in cross-sectional MRI.</p> Results <p>Amygdala-predominant LB associated with specific deficits in neuropsychological testing compared with those without LB and with limbic LB (<i>p</i> ≤ 0.05). This was accompanied by focal atrophy of the right amygdala compared with those without LB co-pathology (<i>p</i> ≈ 0.02), although this result did not survive false discovery rate correction.</p> Discussion <p>These results suggest that amygdala-predominant LB is an important form of co-pathology in ADNC, associating with cognitive decline and focal brain atrophy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Amygdala-predominant Lewy bodies associate with cognitive decline and amygdala atrophy in Alzheimer’s disease neuropathological change

  • 期刊论文

  • 发表日期：

    2025年9月12日

查看全文
  • Francisco C. Almeida,
  • Alexandra Santos,
  • Tiago Jesus,
  • Kathryn Gauthreaux,
  • Charles N. Mock,
  • Walter A. Kukull,
  • John F. Crary,
  • Tiago Gil Oliveira

摘要

Introduction

Amygdala-predominant Lewy body (LB) pathology occurs frequently in association with advanced Alzheimer’s disease (AD). Its clinical significance is not yet fully clarified. We investigated the influence of amygdala-predominant LB in cognitive profiles and brain atrophy in the context of AD neuropathological change (ADNC).

Methods

We performed a retrospective cohort study from the National Alzheimer’s Coordinating Center dataset assessing the influence of amygdala-predominant LB and caudo-rostral LB stages in longitudinal neuropsychological and cognitive testing, as well as on regional brain volume in cross-sectional MRI.

Results

Amygdala-predominant LB associated with specific deficits in neuropsychological testing compared with those without LB and with limbic LB (p ≤ 0.05). This was accompanied by focal atrophy of the right amygdala compared with those without LB co-pathology (p ≈ 0.02), although this result did not survive false discovery rate correction.

Discussion

These results suggest that amygdala-predominant LB is an important form of co-pathology in ADNC, associating with cognitive decline and focal brain atrophy.