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<p>Epilepsy is a chronic neurological disorder. Although anti-seizure medications (ASMs) are currently primary treatment for epilepsy, about one-third of patients develop drug resistant epilepsy (DRE). Relevant studies have found that astrocytes are not only involved in regulating the metabolism of neuronal networks, but are also closely associated with the development of neuroinflammation, both of which are related to the development of DRE. Therefore, we performed a deep exploration of the relationship between astrocytes abnormal metabolism and neuroinflammation, hoping to provide new insights into therapeutic approaches for DRE.</p>

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Correlation between metabolism and neuroinflammation of astrocytes in drug-resistant epilepsy

  • 期刊论文

  • 发表日期：

    2025年9月11日

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  • Xiao-xiao Yu,
  • Da Xu,
  • Shuang Chen,
  • Qiang Liu,
  • Hai-jun Wang,
  • Man Li

摘要

Epilepsy is a chronic neurological disorder. Although anti-seizure medications (ASMs) are currently primary treatment for epilepsy, about one-third of patients develop drug resistant epilepsy (DRE). Relevant studies have found that astrocytes are not only involved in regulating the metabolism of neuronal networks, but are also closely associated with the development of neuroinflammation, both of which are related to the development of DRE. Therefore, we performed a deep exploration of the relationship between astrocytes abnormal metabolism and neuroinflammation, hoping to provide new insights into therapeutic approaches for DRE.