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<p>The relationship between hearing impairment and dementia has attracted significant attention, the 2024 Lancet Commission report identifying hearing loss as the largest modifiable risk factor for dementia from mid-life. The nature of this linkage between dementia and hearing remains unclear and is likely to be complex. In principle, hearing impairment could cause (directly promote), catalyze (amplify) or be a consequence of neurodegenerative pathology and cognitive decline. Here we use this framework to examine different lines of evidence for the association between hearing impairment and dementia, and consider how this evidence speaks to potential mechanisms and treatment implications. We conclude by considering practical clinical implications for management of patients with hearing impairment and dementia, the potential role for central hearing tests as ‘auditory biomarkers’ of dementia, and the need for further collaborative and mechanistically motivated research in this area.</p>

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Hearing impairment and dementia: cause, catalyst or consequence?

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月16日

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  • Benjamin A. Levett,
  • Avinash Chandra,
  • Jessica Jiang,
  • Nehzat Koohi,
  • Dale Sharrad,
  • Lucy B. Core,
  • Jeremy C. S. Johnson,
  • Madison Tutton,
  • Tim Green,
  • Dona M. P. Jayakody,
  • Jin-Tai Yu,
  • Iracema Leroi,
  • Charles R. Marshall,
  • Doris-Eva Bamiou,
  • Chris J. D. Hardy,
  • Jason D. Warren

摘要

The relationship between hearing impairment and dementia has attracted significant attention, the 2024 Lancet Commission report identifying hearing loss as the largest modifiable risk factor for dementia from mid-life. The nature of this linkage between dementia and hearing remains unclear and is likely to be complex. In principle, hearing impairment could cause (directly promote), catalyze (amplify) or be a consequence of neurodegenerative pathology and cognitive decline. Here we use this framework to examine different lines of evidence for the association between hearing impairment and dementia, and consider how this evidence speaks to potential mechanisms and treatment implications. We conclude by considering practical clinical implications for management of patients with hearing impairment and dementia, the potential role for central hearing tests as ‘auditory biomarkers’ of dementia, and the need for further collaborative and mechanistically motivated research in this area.