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Background <p>London taxi drivers’ navigationally challenged hippocampi are known to be enlarged, and reduced Alzheimer’s disease (AD)-related mortality has recently been shown in similarly well-versed drivers, implying a neuroprotective effect through hippocampal engagement. Vestibular function has been linked to hippocampal size, suggesting that vestibular input may influence AD risk.</p> Methods <p>Including 16 known modifiable lifestyle factors as covariates, we analyzed UK Biobank (UKB) volunteers aged over 55 years and without dementia at baseline to assess how peripheral vestibular dysfunction (PVD) influences the likelihood of an AD diagnosis.</p> Results <p>4684 AD and 2133 PVD cases were identified based on their ICD diagnoses; even accounting for other risk factors, PVD increased the risk of AD 1.7 times in UKB volunteers.</p> Discussion <p>Vestibular loss, linked to hippocampal atrophy and default mode network disruption, appears to increase AD risk. Consequently, active vestibular stimulation by balance training or neuromodulation could offer potential for modifying AD progression.</p>

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Vestibular dysfunction: a hidden risk factor for Alzheimer’s disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月25日

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  • Carolin Anna Maria Koriath,
  • Boris Rauchmann,
  • Florian Schoeberl,
  • Andreas Zwergal,
  • Peter Falkai,
  • Robert Perneczky

摘要

Background

London taxi drivers’ navigationally challenged hippocampi are known to be enlarged, and reduced Alzheimer’s disease (AD)-related mortality has recently been shown in similarly well-versed drivers, implying a neuroprotective effect through hippocampal engagement. Vestibular function has been linked to hippocampal size, suggesting that vestibular input may influence AD risk.

Methods

Including 16 known modifiable lifestyle factors as covariates, we analyzed UK Biobank (UKB) volunteers aged over 55 years and without dementia at baseline to assess how peripheral vestibular dysfunction (PVD) influences the likelihood of an AD diagnosis.

Results

4684 AD and 2133 PVD cases were identified based on their ICD diagnoses; even accounting for other risk factors, PVD increased the risk of AD 1.7 times in UKB volunteers.

Discussion

Vestibular loss, linked to hippocampal atrophy and default mode network disruption, appears to increase AD risk. Consequently, active vestibular stimulation by balance training or neuromodulation could offer potential for modifying AD progression.