Subtypes of cognitive impairment in cerebellar disease identified by cross-diagnostic cluster-analysis: results from a German multicenter study

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2024年12月21日

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Qi Liu,
Kerstin Rubarth,
Jennifer Faber,
Patricia Sulzer,
Imis Dogan,
Miriam Barkhoff,
Martina Minnerop,
Adam M. Berlijn,
Saskia Elben,
Heike Jacobi,
Julia-Elisabeth Aktories,
Dana M. Huvermann,
Friedrich Erdlenbruch,
Raquel Van der Veen,
Johanna Müller,
Enzo Nio,
Benedikt Frank,
Martin Köhrmann,
Elke Wondzinski,
Mario Siebler,
Kathrin Reetz,
Jürgen Konczak,
Frank Konietschke,
Thomas Klockgether,
Matthis Synofzik,
Sandra Röske,
Dagmar Timmann,
Andreas Thieme

摘要

Background

Cognitive and neuropsychiatric impairment, known as cerebellar cognitive affective syndrome (CCAS), may be present in cerebellar disorders. This study identified distinct CCAS subtypes in cerebellar patients using cluster analysis.

Methods

The German CCAS-Scale (G-CCAS-S), a brief screening test for CCAS, was assessed in 205 cerebellar patients and 200 healthy controls. K-means cluster analysis was applied to G-CCAS-S data to identify cognitive clusters in patients. Demographic and clinical variables were used to characterize the clusters. Multiple linear regression quantified their relative contribution to cognitive performance. The ability of the G-CCAS-S to correctly distinguish between patients and controls was compared across the clusters.

Results

Two clusters explained the variance of cognitive performance in patients’ best. Cluster 1 (30%) exhibited severe impairment. Cluster 2 (70%) displayed milder dysfunction and overlapped substantially with that of healthy controls. Cluster 1 patients were on average older, less educated, showed more severe ataxia and more extracerebellar involvement than cluster 2 patients. The cluster assignment predicted cognitive performance even after adjusting for all other covariates. The G-CCAS-S demonstrated good discriminative ability for cluster 1, but not for cluster 2.

Conclusions

The variance of cognitive impairment in cerebellar disorders is best explained by one severely affected and one mildly affected cluster. Cognitive performance is not only predicted by demographic/clinical characteristics, but also by cluster assignment itself. This indicates that factors that have not been captured in this study likely have effects on cognitive cerebellar functions. Moreover, the CCAS-S appears to have a relative weakness in identifying patients with only mild cognitive deficits.

Study registration

The study has prospectively been registered at the German Clinical Study Register (https://www.drks.de; DRKS-ID: DRKS00016854).