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Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2024年12月12日

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  • Manuel Comabella,
  • Harald Hegen,
  • Luisa M. Villar,
  • Konrad Rejdak,
  • Augusto Sao-Avilés,
  • Malina Behrens,
  • Jaume Sastre-Garriga,
  • Neus Mongay,
  • Klaus Berek,
  • Sergio Martínez-Yelamos,
  • Francisco Pérez-Miralles,
  • Ahmed Abdelhak,
  • Franziska Bachhuber,
  • Hayrettin Tumani,
  • Jan Lycke,
  • Pere Carbonell-Mirabent,
  • Adrián Valls-Carbó,
  • Igal Rosenstein,
  • Roberto Alvarez-Lafuente,
  • Tamara Castillo-Triviño,
  • David Otaegui,
  • Sara Llufriu,
  • Yolanda Blanco,
  • Antonio J. Sánchez-López,
  • Antonio García-Merino,
  • Nicolás Fissolo,
  • Lucía Gutiérrez,
  • Javier Villacieros-Álvarez,
  • Enric Monreal,
  • Heinz Wiendl,
  • Xavier Montalban,
  • Jan D. Lünemann

摘要

Background and objectives

The impact of viral infections on disease susceptibility and progression has predominantly been studied in patients with relapse-onset MS (RMS). Here, we determined immune responses to ubiquitous viruses in patients with primary progressive MS (PPMS).

Methods

Antibody responses to Epstein–Barr virus (EBV), specifically to the latent EBV nuclear antigen 1 and the lytic viral capsid antigen VCA, human herpesvirus 6 (HHV-6), human cytomegalovirus (HCMV), and measles virus were determined in a cohort of 68 PPMS patients with a mean follow-up of 8 years and compared with 66 healthy controls matched for sex and age.

Results

Compared with controls, PPMS patients showed increased humoral immune responses to the EBV-encoded nuclear antigen-1 (EBNA1), but not to the lytic EBV capsid antigen (VCA) or to other viral antigens. Seroprevalence rates for HCMV were significantly higher in PPMS. Antiviral immune responses at baseline did not correlate with disability progression over time.

Discussion

Elevated immune responses toward EBNA1 are selectively increased in people with primary progressive disease, indicating a link between EBNA1-targeting immune responses and the development of both RMS and PPMS. Our data also suggest that chronic HCMV infection is associated with progressive MS.