Mid- and late-life lifestyle activities as main drivers of general and domain-specific cognitive reserve in individuals with Parkinson’s disease: cross-sectional and longitudinal evidence from the LANDSCAPE study

期刊论文
出版模式：

开放获取
发表日期：

2024年7月1日

查看全文

Anja Ophey,
Kathrin Wirtz,
Steffen Wolfsgruber,
Monika Balzer-Geldsetzer,
Daniela Berg,
Rüdiger Hilker-Roggendorf,
Jan Kassubek,
Inga Liepelt-Scarfone,
Sara Becker,
Britt Mollenhauer,
Kathrin Reetz,
Oliver Riedel,
Jörg B. Schulz,
Alexander Storch,
Claudia Trenkwalder,
Karsten Witt,
Hans-Ullrich Wittchen,
Richard Dodel,
Sandra Roeske,
Elke Kalbe

摘要

Background

Cognitive reserve (CR) is considered a protective factor for cognitive function and may explain interindividual differences of cognitive performance given similar levels of neurodegeneration, e.g., in Alzheimer´s disease. Recent evidence suggests that CR is also relevant in Parkinson’s disease (PD).

Objective

We aimed to explore the role of life-stage specific CR for overall cognition and specific cognitive domains cross-sectionally and longitudinally in PD.

Methods

The cross-sectional analysis with data from the DEMPARK/LANDSCAPE study included 81 individuals without cognitive impairment (PD-N) and 87 individuals with mild cognitive impairment (PD-MCI). Longitudinal data covered 4 years with over 500 observations. CR was operationalized with the Lifetime of Experiences Questionnaire (LEQ), capturing the complexity of lifestyle activities across distinct life-stages. Cognition was assessed using a comprehensive neuropsychological test battery.

Results

Higher LEQ scores, particularly from mid- and late-life, were observed in PD-N compared to PD-MCI [F(1,153) = 4.609, p = .033, η_p² = 0.029]. They were significantly associated with better cognitive performance (0.200 ≤ β ≤ 0.292). Longitudinally, linear mixed effect models (0.236 ≤ marginal R² ≤ 0.441) revealed that LEQ scores were positively related to cognitive performance independent of time. However, the decline in overall cognition and memory over time was slightly more pronounced with higher LEQ scores.

Conclusions

This study emphasizes the association between complex lifestyle activities and cognition in PD. Data indicate that while CR might be related to a delay of cognitive decline, individuals with high CR may experience a more pronounced drop in overall cognition and memory. Future studies will have to replicate these findings, particularly regarding domain-specific effects and considering reverse causal mechanisms.