Different pain phenotypes are associated with anti-Caspr2 autoantibodies

期刊论文
出版模式：

开放获取
发表日期：

2024年2月22日

查看全文

Patrik Greguletz,
Maria Plötz,
Carolin Baade-Büttner,
Christian G. Bien,
Katharina Eisenhut,
Christian Geis,
Robert Handreka,
Jaqueline Klausewitz,
Peter Körtvelyessy,
Stjepana Kovac,
Andrea Kraft,
Jan Lewerenz,
Michael Malter,
Michael Nagel,
Felix von Podewils,
Harald Prüß,
Anna Rada,
Johanna Rau,
Sebastian Rauer,
Rosa Rößling,
Thomas Seifert-Held,
Kai Siebenbrodt,
Kurt-Wolfram Sühs,
Simone C. Tauber,
Franziska Thaler,
Judith Wagner,
Jonathan Wickel,
Frank Leypoldt,
Heike L. Rittner,
Claudia Sommer,
Carmen Villmann,
Kathrin Doppler,
Michael Adelmann,
Luise Appeltshauser,
Ilya Ayzenberg,
Andreas van Baalen,
Sebastian Baatz,
Oliver Bähr,
Bettina Balint,
Sebastian Bauer,
Annette Baumgartner,
Stefanie Becker,
Sonka Benesch,
Robert Berger,
Birgit Berger,
Martin Berghoff,
Sascha Berning,
Sarah Bernsen,
Achim Berthele,
Christian Bien,
Corinna Bien,
Andreas Binder,
Stefan Bittner,
Daniel Bittner,
Franz Blaes,
Astrid Blaschek,
Amelie Bohn,
Sergio Castro-Gomez,
Justina Dargvainiene,
Timo Deba,
Julia Maren Decker,
Andre Dik,
Juliane Dominik,
Mona Dreesmann,
Friedrich Ebinger,
Lena Edelhoff,
Laura Ehrhardt,
Sven Ehrlich,
Alexander Emmer,
Dominique Endres,
Marina Entscheva,
Daniela Esser,
Thorleif Etgen,
Jürgen Hartmut Faiss,
Kim Kristin Falk,
Walid Fazeli,
Alexander Finke,
Carsten Finke,
Dirk Fitzner,
Marina Flotats-Bastardas,
Mathias Fousse,
Tobias Freilinger,
Paul Friedemann,
Manuel Friese,
Marco Gallus,
Marcel Gebhard,
Anna Gorsler,
Armin Grau,
Oliver Grauer,
Britta Greshake,
Catharina Groß,
Thomas Grüter,
Aiden Haghikia,
Niels Hansen,
Jens Harmel,
Antonia Harms,
Yetzenia Dubraska Haro Alizo,
Martin Häusler,
Joachim Havla,
Chung Ha-Yeun,
Wolfgang Heide,
Valentin Held,
Kerstin Hellwig,
Philip Hillebrand,
Frank Hoffmann,
Christian Hofmann,
Ulrich Hofstadt-van Oy,
Peter Huppke,
Hagen Huttner,
Fatme Seval Ismail,
Martina Jansen,
Mareike Jansen,
Aleksandra Juranek,
Michael Karenfort,
Max Kaufmann,
Christoph Kellinghaus,
Constanze Kerin (geb. Mönig),
Susanne Knake,
Ellen Knierim,
Peter Körtvélyessy,
Markus Krämer,
Verena Kraus,
Christos Krogias,
Gregor Kuhlenbäumer,
Tanja Kümpfel,
Christoph Lehrich,
Andeas Linsa,
Jan Lünemann,
Marie Madlener,
Niels Margraf,
Carlos Martinez Quesada,
Monika Meister,
Nico Melzer,
Kristin Stefanie Melzer,
Til Menge,
Sven Meuth,
Gerd Meyer zu Hörste,
Fabian Möller,
Marie-Luise Mono,
Sigrid Mues,
Jost Obrocki,
Loana Penner,
Lena Kristina Pfeffer,
Thomas Pfefferkorn,
Steffen Pfeuffer,
Alexandra Philipsen,
Johannes Piepgras,
Felix von Poderwils,
Mosche Pompsch,
Josef Priller,
Anne-Katrin Pröbstel,
Daniel Rapp,
Dominica Ratuszny,
Johanna Maria Helena Rau,
Saskia Jania Räuber,
Robert Rehmann,
Ina Reichen,
Gernot Reimann,
Raphael Reinecke,
Nele Retzlaff,
Marius Ringelstein,
Henrik Rohner,
Felix Rosenow,
Kevin Rostasy,
Theodor Rüber,
Stephan Rüegg,
Yannic Saathoff,
Jens Schaumberg,
Ruth Schilling,
Mareike Schimmel,
Jens Schmidt,
Ina-Isabelle Schmütz,
Hauke Schneider,
Patrick Schramm,
Stephan Schreiber,
Gesa Schreyer,
Ina Schröder,
Simon Schuster,
Günter Seidel,
Frank Seifert,
Makbule Senel,
Olga Simova,
Juliane Spiegler,
Oliver Stammel,
Andeas Steinbrecher,
Henning Stolze,
Muriel Stoppe,
Karin van`s Gravesande Storm,
Christine Strippel,
Dietrich Sturm,
Klarissa Hanja Stürner,
Steffen Syrbe,
Pawel Tacik,
Simone Tauber,
Florian Then Bergh,
Anja Tietz,
Corinna Trebst,
George Trendelenburg,
Regina Trollmann,
Thanos Tsaktanis,
Hayrettin Tumani,
Methap Türedi,
Christian Urbanek,
Niklas Vogel,
Max Vogtmann,
Matthias von Mering,
Jan Wagner,
Klaus-Peter Wandinger,
Robert Weissert,
Brigitte Wildemann,
Karsten Witt,
Kartharina Wurdack,
Lara Zieger

摘要

Autoantibodies against contactin-associated protein 2 (Caspr2) not only induce limbic autoimmune encephalitis but are also associated with pain conditions. Here, we analyzed clinical data on pain in a large cohort of patients included into the German Network for Research in Autoimmune Encephalitis. Out of 102 patients in our cohort, pain was a frequent symptom (36% of all patients), often severe (63.6% of the patients with pain) and/or even the major symptom (55.6% of the patients with pain). Pain phenotypes differed between patients. Cluster analysis revealed two major phenotypes including mostly distal-symmetric burning pain and widespread pain with myalgia and cramps. Almost all patients had IgG4 autoantibodies and some additional IgG1, 2, and/or 3 autoantibodies, but IgG subclasses, titers, and presence or absence of intrathecal synthesis were not associated with the occurrence of pain. However, certain pre-existing risk factors for chronic pain like diabetes mellitus, peripheral neuropathy, or preexisting chronic back pain tended to occur more frequently in patients with anti-Caspr2 autoantibodies and pain. Our data show that pain is a relevant symptom in patients with anti-Caspr2 autoantibodies and support the idea of decreased algesic thresholds leading to pain. Testing for anti-Caspr2 autoantibodies needs to be considered in patients with various pain phenotypes.