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<p>A highly sensitive analytical method for the detection of succinylcholine (SUX) and its metabolite (succinylmonocholine, SMC) in hair was established using liquid chromatography-tandem mass spectrometry with ion-pair solid-phase extraction (IP-SPE), and was applied in a murder case. SUX and SMC were detected using this method, for the first time, in hair collected from a victim 27&#xa0;days after SUX injection. To investigate the distributions of SUX and SMC along hair, 2-mm sectional quantitative analysis was performed on the 0–2&#xa0;cm segment, the hair region which was positive for the analytes. SUX and SMC were detected in the ranges of 4–14&#xa0;mm and 6–14&#xa0;mm from the root end, respectively, both with the highest concentrations in the 8–10&#xa0;mm segment, which would be roughly consistent with the SUX injection to the victim 27&#xa0;days earlier. The detected concentrations of SUX and SMC in the 0–2&#xa0;cm segment were 1.0&#xa0;pg/hair strand (8.3&#xa0;pg/mg) and 0.18&#xa0;pg/hair strand (1.5&#xa0;pg/mg), respectively. These data demonstrate the present method has sufficient LODs to detect SUX and SMC incorporated in hair, and hair testing could be useful to prove SUX injections in the forensic fields.</p>

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Optimization of an analytical method for succinylcholine and its metabolite in hair and its forensic application in a murder case

  • 期刊论文

  • 发表日期：

    2026年4月23日

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  • Keiko Sasaki,
  • Hiroe Kamata,
  • Misato Wada,
  • Atsushi Nitta,
  • Noriaki Shima,
  • Fumiya Morioka,
  • Munehiro Katagi,
  • Takako Sato,
  • Hiroshi Nishioka

摘要

A highly sensitive analytical method for the detection of succinylcholine (SUX) and its metabolite (succinylmonocholine, SMC) in hair was established using liquid chromatography-tandem mass spectrometry with ion-pair solid-phase extraction (IP-SPE), and was applied in a murder case. SUX and SMC were detected using this method, for the first time, in hair collected from a victim 27 days after SUX injection. To investigate the distributions of SUX and SMC along hair, 2-mm sectional quantitative analysis was performed on the 0–2 cm segment, the hair region which was positive for the analytes. SUX and SMC were detected in the ranges of 4–14 mm and 6–14 mm from the root end, respectively, both with the highest concentrations in the 8–10 mm segment, which would be roughly consistent with the SUX injection to the victim 27 days earlier. The detected concentrations of SUX and SMC in the 0–2 cm segment were 1.0 pg/hair strand (8.3 pg/mg) and 0.18 pg/hair strand (1.5 pg/mg), respectively. These data demonstrate the present method has sufficient LODs to detect SUX and SMC incorporated in hair, and hair testing could be useful to prove SUX injections in the forensic fields.