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Purpose <p>The cough severity visual analogue scale (VAS) and the Leicester Cough Questionnaire (LCQ) are commonly used in chronic cough. While continuous scores are useful for tracking change, categorization is needed to define clinically relevant states. However, patient-anchored thresholds for cough control remain undefined.</p> Methods <p>Using the Korean Chronic Cough Registry (<i>n</i> = 890), we derived VAS and LCQ cutoffs anchored to a patient-reported cough control item. Receiver operating characteristic (ROC) analyses were performed using operational definitions of very well-controlled cough (“strongly agree” vs. all others), well-controlled cough (“strongly agree” + “agree” vs. all others), and uncontrolled cough (“disagree” + “strongly disagree” vs. all others).</p> Results <p>Both scores demonstrated stepwise gradients across cough control categories (<i>p</i> &lt; 0.001). ROC-derived cutoffs for very well-controlled cough were VAS ≤ 10 (area under the curve [AUC], 0.911) and LCQ ≥ 15.8 (AUC, 0.877). For well-controlled cough, the corresponding cutoffs were VAS ≤ 30 (AUC, 0.866) and LCQ ≥ 15 (AUC, 0.856). For uncontrolled cough, the cutoffs were VAS ≥ 50 (AUC, 0.879) and LCQ ≤ 13.0 (AUC, 0.872). Cutoffs were consistent across newly referred chronic cough and refractory chronic cough subgroups. Concordance between VAS- and LCQ-derived classifications was moderate-to-substantial (weighted kappa = 0.55).</p> Conclusion <p>Based on these findings, we propose a patient-anchored classification framework for cough control: very well-controlled cough (VAS ≤ 10, LCQ ≥ 16), well-controlled cough (VAS 11–30, LCQ 15.0–15.9), intermediate cough control (VAS 31–49, LCQ 13.1–14.9), and uncontrolled cough (VAS ≥ 50, LCQ ≤ 13). These thresholds warrant validation in diverse populations.</p>

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Patient-Anchored Cough Visual Analogue Scale and Leicester Cough Questionnaire Thresholds for Cough Control Classification in Chronic Cough

  • 期刊论文

  • 发表日期：

    2026年7月21日

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  • Minkyo Suh,
  • Ji-Yoon Oh,
  • Ha-Kyeong Won,
  • Ji-Hyang Lee,
  • Young-Chan Kim,
  • Eun-Jung Jo,
  • Sung-Yoon Kang,
  • So-Young Park,
  • Hwa Young Lee,
  • Mi-Yeong Kim,
  • Kyung-Min Ahn,
  • Ji-Su Shim,
  • Min-Hye Kim,
  • Jiung Jeong,
  • Han-Ki Park,
  • So Ri Kim,
  • Sang-Heon Kim,
  • Yoon-Seok Chang,
  • Sang-Hoon Kim,
  • Byung-Jae Lee,
  • Surinder S. Birring,
  • Woo-Jung Song,
  • Jin An,
  • Surinder S. Birring,
  • Yoon-Seok Chang,
  • Sang-Heon Cho,
  • Kian Fan Chung,
  • Eun-Jung Jo,
  • Jiung Jeong,
  • Noeul Kang,
  • Sung-Yoon Kang,
  • Byung-Keun Kim,
  • Mi-Yeong Kim,
  • Min-Hye Kim,
  • Sae-Hoon Kim,
  • Sang-Heon Kim,
  • Sang-Hoon Kim,
  • So Ri Kim,
  • Young-Chan Kim,
  • Hyouk-Soo Kwon,
  • Byung-Jae Lee,
  • Ji-Ho Lee,
  • Ji-Hyang Lee,
  • Hwa Young Lee,
  • Seung-Eun Lee,
  • Ji-Yong Moon,
  • Alyn H. Morice,
  • Ji-Yoon Oh,
  • Han-Ki Park,
  • So-Young Park,
  • Ji-Su Shim,
  • Min-Hye Shin,
  • Woo-Jung Song,
  • Ha-Kyeong Won,
  • Youngsang Yoo

摘要

Purpose

The cough severity visual analogue scale (VAS) and the Leicester Cough Questionnaire (LCQ) are commonly used in chronic cough. While continuous scores are useful for tracking change, categorization is needed to define clinically relevant states. However, patient-anchored thresholds for cough control remain undefined.

Methods

Using the Korean Chronic Cough Registry (n = 890), we derived VAS and LCQ cutoffs anchored to a patient-reported cough control item. Receiver operating characteristic (ROC) analyses were performed using operational definitions of very well-controlled cough (“strongly agree” vs. all others), well-controlled cough (“strongly agree” + “agree” vs. all others), and uncontrolled cough (“disagree” + “strongly disagree” vs. all others).

Results

Both scores demonstrated stepwise gradients across cough control categories (p < 0.001). ROC-derived cutoffs for very well-controlled cough were VAS ≤ 10 (area under the curve [AUC], 0.911) and LCQ ≥ 15.8 (AUC, 0.877). For well-controlled cough, the corresponding cutoffs were VAS ≤ 30 (AUC, 0.866) and LCQ ≥ 15 (AUC, 0.856). For uncontrolled cough, the cutoffs were VAS ≥ 50 (AUC, 0.879) and LCQ ≤ 13.0 (AUC, 0.872). Cutoffs were consistent across newly referred chronic cough and refractory chronic cough subgroups. Concordance between VAS- and LCQ-derived classifications was moderate-to-substantial (weighted kappa = 0.55).

Conclusion

Based on these findings, we propose a patient-anchored classification framework for cough control: very well-controlled cough (VAS ≤ 10, LCQ ≥ 16), well-controlled cough (VAS 11–30, LCQ 15.0–15.9), intermediate cough control (VAS 31–49, LCQ 13.1–14.9), and uncontrolled cough (VAS ≥ 50, LCQ ≤ 13). These thresholds warrant validation in diverse populations.