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Purpose <p>Pulmonary fibrosis may impair an individual’s ability to work. We assessed the extent, cost and factors associated with workplace productivity loss among patients with progressive pulmonary fibrosis (PPF).</p> Methods <p>The multi-center ILD-PRO Registry enrolled US patients with progressive interstitial lung diseases (ILDs) other than idiopathic pulmonary fibrosis. Workplace productivity loss was assessed using the Work Productivity and Activity Impairment (WPAI) questionnaire. Associations between patient characteristics and workplace productivity loss among employed patients were analyzed using logistic regression.</p> Results <p>Among 175 employed patients of 597 who completed the WPAI questionnaire, 58.3% were female, median age was 58 years, median forced vital capacity (FVC) was 58.7% predicted; 20.0% used oxygen with activity and at rest. In the past 7 days, mean (SD) hours worked was 32.9 (15.8) and mean (SD) working hours lost was 10 (12). Mean (SD) percentage of working hours lost was 24.4 (30.2). Mean (SD) working hours lost due to absenteeism and presenteeism were 4 (9) and 8 (11), respectively. Among patients with any productivity loss, the estimated mean (SD) annual cost of productivity loss was $24,815 ($17,917). Lower FVC % predicted, higher (worse) St. George’s Respiratory Questionnaire scores and lower (worse) Cough and Sputum Assessment Questionnaire cough impact and symptoms scores were associated with greater odds of productivity loss.</p> Conclusions <p>Patients with PPF showed significant impairment in workplace productivity. Worse lung function and worse scores on patient-reported outcomes were associated with a greater likelihood of productivity loss.</p> <p><i>Trial Registration</i> ClinicalTrials.gov; No: NCT01915511; registered August 5, 2013; <a href="http://www.clinicaltrials.gov">URL: www.clinicaltrials.gov</a>.</p>

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Workplace Productivity Loss in Patients with Progressive Pulmonary Fibrosis: Data from the ILD-PRO Registry

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月27日

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  • Sharashchandra Shetty,
  • Aparna C. Swaminathan,
  • Peide Li,
  • Megan L. Neely,
  • Amy L Olson,
  • Laurie D. Snyder,
  • Albert Baker,
  • Debabrata Bandyopadhyay,
  • Scott Beegle,
  • John A. Belperio,
  • Domingo Chardon,
  • Rany Condos,
  • Daniel Dilling,
  • Bradford Bemiss,
  • John Fitzgerald,
  • Kevin R. Flaherty,
  • Reginald Fowler,
  • Mridu Gulati,
  • Nishant Gupta,
  • Amy Hajari Case,
  • Mark Hamblin,
  • David Hotchkin,
  • Robert J. Kaner,
  • Jad Kebbe,
  • Hyun J. Kim,
  • Ena Gupta,
  • Justin Hewlett,
  • Joseph A. Lasky,
  • Hector Sanchez,
  • Victor Pinto-Plata,
  • Randolph Lipchik,
  • LJason Lobo,
  • Tracy R. Luckhardt,
  • Yolanda Mageto,
  • Toby M. Maher,
  • Lake Morrison,
  • Andrew Namen,
  • Tessy Paul,
  • Mary Porteous,
  • Rishi Raj,
  • Murali Ramaswamy,
  • Jesse Roman,
  • Ivan Rosas,
  • Tonya Russell,
  • Zeenat Safdar,
  • Gabrielle Liu,
  • Brian Southern,
  • Mary E. Strek,
  • Srihari Veeraraghavan,
  • Rajat Walia,
  • Timothy P. M. Whelan

摘要

Purpose

Pulmonary fibrosis may impair an individual’s ability to work. We assessed the extent, cost and factors associated with workplace productivity loss among patients with progressive pulmonary fibrosis (PPF).

Methods

The multi-center ILD-PRO Registry enrolled US patients with progressive interstitial lung diseases (ILDs) other than idiopathic pulmonary fibrosis. Workplace productivity loss was assessed using the Work Productivity and Activity Impairment (WPAI) questionnaire. Associations between patient characteristics and workplace productivity loss among employed patients were analyzed using logistic regression.

Results

Among 175 employed patients of 597 who completed the WPAI questionnaire, 58.3% were female, median age was 58 years, median forced vital capacity (FVC) was 58.7% predicted; 20.0% used oxygen with activity and at rest. In the past 7 days, mean (SD) hours worked was 32.9 (15.8) and mean (SD) working hours lost was 10 (12). Mean (SD) percentage of working hours lost was 24.4 (30.2). Mean (SD) working hours lost due to absenteeism and presenteeism were 4 (9) and 8 (11), respectively. Among patients with any productivity loss, the estimated mean (SD) annual cost of productivity loss was $24,815 ($17,917). Lower FVC % predicted, higher (worse) St. George’s Respiratory Questionnaire scores and lower (worse) Cough and Sputum Assessment Questionnaire cough impact and symptoms scores were associated with greater odds of productivity loss.

Conclusions

Patients with PPF showed significant impairment in workplace productivity. Worse lung function and worse scores on patient-reported outcomes were associated with a greater likelihood of productivity loss.

Trial Registration ClinicalTrials.gov; No: NCT01915511; registered August 5, 2013; URL: www.clinicaltrials.gov.