Scholarlink

Background <p>The neurobiological mechanisms underlying the therapeutic effects of meditation therapy in patients with schizophrenia remain poorly understood, therefore, we aim to investigate the relationship between clinical symptoms and the structural changes in brain gray matter in a meditation intervention trial.</p> Methods <p>Han inpatients with schizophrenia admitted to the Shanghai First Civil Affairs Mental Health Centre in 2018 were recruited and randomly assigned to the meditation (Med) or the conventional (CON) treatment group in an eight-months trial. MRI data was collected at the outset, three months, and eight months of treatment.</p> Results <p>Fifty-eight male subjects completed all evaluations and MRI scans, including 30 in Med and 28 in CON. The findings indicate that meditation can significantly inhibit the extensive regional atrophy of gray matter volume (GMV). A positive correlation was observed between the GMV change rate in the right thalamus and the reduction rate of PANSS positive score (<i>r =</i> 0.3850, <i>p =</i> 0.0028), negative score (<i>r =</i> 0.3789, <i>p =</i> 0.0034) and total score (<i>r =</i> 0.3705, <i>p =</i> 0.0042); The GMV change rate in right insula was positively correlated with PANSS positive score (<i>r =</i> 0.2976, <i>p =</i> 0.0233), negative score (<i>r =</i> 0.3987, <i>p =</i> 0.0019), general score (<i>r =</i> 0.3216, <i>p =</i> 0.0138) and total score (<i>r =</i> 0.3765, <i>p =</i> 0.0035). Additionally, the GMV change rate in the right supplementary motor area was positively correlated with negative scores (<i>r =</i> 0.3633, <i>p =</i> 0.0051). while the right paracentral lobule positively correlated with PANSS general score (<i>r =</i> 0.2791, <i>p =</i> 0.0338).</p> Conclusion <p>These findings demonstrate the effectiveness of meditation in chronic schizophrenia and suggest it as a promising method for the alleviation of clinical symptoms in schizophrenia.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of meditation on clinical symptoms and gray matter volume in chronic schizophrenia: a randomized controlled trial

  • 期刊论文

  • 发表日期：

    2026年5月19日

查看全文
  • Mi Yang,
  • Yuzheng Ma,
  • Jialong Huang,
  • Yanqing Huang,
  • Liju Liu,
  • Zezhi Li,
  • Donghong Cui

摘要

Background

The neurobiological mechanisms underlying the therapeutic effects of meditation therapy in patients with schizophrenia remain poorly understood, therefore, we aim to investigate the relationship between clinical symptoms and the structural changes in brain gray matter in a meditation intervention trial.

Methods

Han inpatients with schizophrenia admitted to the Shanghai First Civil Affairs Mental Health Centre in 2018 were recruited and randomly assigned to the meditation (Med) or the conventional (CON) treatment group in an eight-months trial. MRI data was collected at the outset, three months, and eight months of treatment.

Results

Fifty-eight male subjects completed all evaluations and MRI scans, including 30 in Med and 28 in CON. The findings indicate that meditation can significantly inhibit the extensive regional atrophy of gray matter volume (GMV). A positive correlation was observed between the GMV change rate in the right thalamus and the reduction rate of PANSS positive score (r = 0.3850, p = 0.0028), negative score (r = 0.3789, p = 0.0034) and total score (r = 0.3705, p = 0.0042); The GMV change rate in right insula was positively correlated with PANSS positive score (r = 0.2976, p = 0.0233), negative score (r = 0.3987, p = 0.0019), general score (r = 0.3216, p = 0.0138) and total score (r = 0.3765, p = 0.0035). Additionally, the GMV change rate in the right supplementary motor area was positively correlated with negative scores (r = 0.3633, p = 0.0051). while the right paracentral lobule positively correlated with PANSS general score (r = 0.2791, p = 0.0338).

Conclusion

These findings demonstrate the effectiveness of meditation in chronic schizophrenia and suggest it as a promising method for the alleviation of clinical symptoms in schizophrenia.