Background <p> Schizophrenia is a chronic and disabling mental disorder that leads to poor social functioning, low quality of life, and a heavy burden for families and society. In China, service engagement among community-dwelling patients remains insufficient, limiting the effectiveness of treatment and rehabilitation. Existing engagement-focused interventions were developed and evaluated primarily in high-income countries, leaving little evidence for low- and middle-income settings, including China. This study describes the protocol of a randomized controlled trial designed to evaluate the effectiveness and cost-effectiveness of a community-based service engagement intervention for young adults with schizophrenia in China.</p> Methods <p> A single-blind, individually randomized controlled trial will be conducted in community health service centers in Yangpu District, Shanghai, recruiting 192 eligible patients with schizophrenia. Participants will be randomized 1:1 to the intervention or control group. The intervention consists of six individual sessions and three group sessions over three months, focusing on medical-social support, peer-social support, and service engagement facilitation. Primary outcomes include service engagement, attitudes, and health behaviors; secondary outcomes include recovery, symptoms, quality of life, and costs. Data will be analyzed under the intention-to-treat principle using difference-in-differences models, with multiple imputation for missing values. Cost-effectiveness analysis will include direct and indirect costs reported by patients and caregivers.</p> Discussion <p> This trial is among the first in China to evaluate a community intervention for improving service engagement in schizophrenia. If shown to be effective and cost-effective, the program could be scaled up within existing community-based rehabilitation systems, offering practical guidance for policymakers and practitioners to enhance recovery, promote social inclusion, and reduce the burden of care.</p> Trial registration <p>Chinese Clinical Trial Registry (ChiCTR2500113435). Registered, 2025. </p>

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Community-based service engagement intervention for young adults with schizophrenia in China: study protocol for a randomized controlled trial

  • Xuechun Wang,
  • Jia Hu,
  • Miaomiao Zhao,
  • Ruoxi Ding

摘要

Background

Schizophrenia is a chronic and disabling mental disorder that leads to poor social functioning, low quality of life, and a heavy burden for families and society. In China, service engagement among community-dwelling patients remains insufficient, limiting the effectiveness of treatment and rehabilitation. Existing engagement-focused interventions were developed and evaluated primarily in high-income countries, leaving little evidence for low- and middle-income settings, including China. This study describes the protocol of a randomized controlled trial designed to evaluate the effectiveness and cost-effectiveness of a community-based service engagement intervention for young adults with schizophrenia in China.

Methods

A single-blind, individually randomized controlled trial will be conducted in community health service centers in Yangpu District, Shanghai, recruiting 192 eligible patients with schizophrenia. Participants will be randomized 1:1 to the intervention or control group. The intervention consists of six individual sessions and three group sessions over three months, focusing on medical-social support, peer-social support, and service engagement facilitation. Primary outcomes include service engagement, attitudes, and health behaviors; secondary outcomes include recovery, symptoms, quality of life, and costs. Data will be analyzed under the intention-to-treat principle using difference-in-differences models, with multiple imputation for missing values. Cost-effectiveness analysis will include direct and indirect costs reported by patients and caregivers.

Discussion

This trial is among the first in China to evaluate a community intervention for improving service engagement in schizophrenia. If shown to be effective and cost-effective, the program could be scaled up within existing community-based rehabilitation systems, offering practical guidance for policymakers and practitioners to enhance recovery, promote social inclusion, and reduce the burden of care.

Trial registration

Chinese Clinical Trial Registry (ChiCTR2500113435). Registered, 2025.