Scholarlink

Background <p>Sleep traits have been linked to cognitive aging, but observational associations are susceptible to confounding and reverse causation. Using genetically informed polygenic risk scores (PRSs), this study examined associations between genetic liability to sleep traits and cognitive function in an East Asian population. We further assessed whether educational attainment, as a marker of cognitive reserve, modifies these associations.</p> Methods <p>Participants aged ≥ 60 years from the Taiwan Biobank underwent cognitive assessment using the Mini-Mental State Examination (MMSE) at baseline (<i>n</i> = 27,343) and follow-up (<i>n</i> = 6,273; mean follow-up = 3.9 years). PRSs for chronotype, sleep duration, long sleep, short sleep, insomnia, and daytime napping were constructed. Associations with baseline MMSE and longitudinal MMSE change were evaluated, and PRS × education interactions were tested.</p> Results <p>Higher PRSs for early chronotype, longer sleep duration, and long sleep (&gt; 8&#xa0;h) were associated with lower baseline MMSE scores (β range per SD increase: −0.05 to − 0.03), but were not associated with MMSE change over follow-up. A significant interaction was observed between long-sleep PRS and education for MMSE change (p for interaction = 0.0008), with greater decline among individuals with lower educational attainment. In contrast, no association was observed in higher-education groups.</p> Conclusions <p>Genetic liability to early chronotype and long sleep duration is associated with lower late-life cognitive performance, primarily reflecting differences in baseline cognitive status rather than short-term cognitive decline. Higher educational attainment may mitigate cognitive vulnerability associated with genetic predisposition to long sleep, consistent with a cognitive-reserve framework.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Genetic evidence for the associations of sleep patterns with cognitive function in older adults: insights from polygenic scores in the Taiwan biobank

  • 期刊论文

  • 发表日期：

    2026年3月9日

查看全文
  • Chi-Shin Wu,
  • Mei-Chen Lin,
  • Chi-Fung Cheng,
  • Shu-Fen Liao,
  • Mei-Hsin Su,
  • Yi-Jiun Pan,
  • Shi-Heng Wang

摘要

Background

Sleep traits have been linked to cognitive aging, but observational associations are susceptible to confounding and reverse causation. Using genetically informed polygenic risk scores (PRSs), this study examined associations between genetic liability to sleep traits and cognitive function in an East Asian population. We further assessed whether educational attainment, as a marker of cognitive reserve, modifies these associations.

Methods

Participants aged ≥ 60 years from the Taiwan Biobank underwent cognitive assessment using the Mini-Mental State Examination (MMSE) at baseline (n = 27,343) and follow-up (n = 6,273; mean follow-up = 3.9 years). PRSs for chronotype, sleep duration, long sleep, short sleep, insomnia, and daytime napping were constructed. Associations with baseline MMSE and longitudinal MMSE change were evaluated, and PRS × education interactions were tested.

Results

Higher PRSs for early chronotype, longer sleep duration, and long sleep (> 8 h) were associated with lower baseline MMSE scores (β range per SD increase: −0.05 to − 0.03), but were not associated with MMSE change over follow-up. A significant interaction was observed between long-sleep PRS and education for MMSE change (p for interaction = 0.0008), with greater decline among individuals with lower educational attainment. In contrast, no association was observed in higher-education groups.

Conclusions

Genetic liability to early chronotype and long sleep duration is associated with lower late-life cognitive performance, primarily reflecting differences in baseline cognitive status rather than short-term cognitive decline. Higher educational attainment may mitigate cognitive vulnerability associated with genetic predisposition to long sleep, consistent with a cognitive-reserve framework.