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<p>People living with schizophrenia (PLWS) have a reduced life expectancy with cardiovascular disease (CVD) as a major contributor. This article reviews the existing populations and animal studies and summarizes that reduced abundance of Lachnospiraceae, <i>Bacteroides</i>, <i>Faecalibacterium</i>, <i>Ruminococcus</i>, <i>Roseburia</i>, <i>Bifidobacterium</i>,<i> Lactobacillus</i>,<i> Akkermansia</i>, <i>Rikenellaceae</i> and increased abundance of <i>Prevotella</i>, <i>Clostridium</i>, <i>Escherichia</i> in PLWS is one of the probable reasons for the increased risk of CVD prevalence in PLWS by affecting the metabolism of substances related to the development of Schizophrenia (SCZ) and CVD.</p> Graphical abstract <p>Mechanisms of CVD pathogenesis by gut microbiota in PLWS</p> <p></p>

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Gut microbiota: contributing to high CVD prevalence in people living with schizophrenia?

  • 期刊论文

  • 发表日期：

    2025年9月13日

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  • Chuanwen Fu,
  • Xuehui Zhang,
  • Ying Qian,
  • Ximei Wang,
  • Xinqiang Chen,
  • Jia Zeng,
  • Nichang Zhang,
  • Liming Wang,
  • Mingsong Li,
  • Zhengxu Li,
  • Teng Zhang,
  • Yuemei Feng,
  • Jianzhong Yin

摘要

People living with schizophrenia (PLWS) have a reduced life expectancy with cardiovascular disease (CVD) as a major contributor. This article reviews the existing populations and animal studies and summarizes that reduced abundance of Lachnospiraceae, Bacteroides, Faecalibacterium, Ruminococcus, Roseburia, Bifidobacterium, Lactobacillus, Akkermansia, Rikenellaceae and increased abundance of Prevotella, Clostridium, Escherichia in PLWS is one of the probable reasons for the increased risk of CVD prevalence in PLWS by affecting the metabolism of substances related to the development of Schizophrenia (SCZ) and CVD.

Graphical abstract

Mechanisms of CVD pathogenesis by gut microbiota in PLWS