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<p>This study investigated cerebral blood flow characteristics using functional nearinfrared spectroscopy (fNIRS) in agomelatine-treated depressed patients with anhedonia. The level of anhedonia was assessed by the Snaith Hamilton Rating Scale (SHAPS) and Montgomery Åsberg Depression Rating Scale 5-item (MADRS 5-item) score. All 84 patients were evaluated on the day of the study initiation and followed at week 1, 4 and 8 after the study initiation. Graph theory-based network analysis showed 2-back task-modulated global efficiency (adjusted B = 0.055, 95% CI = 0.043 - 0.066) and local efficiency (adjusted B = 0.066, 95% CI = 0.050 - 0.081) were significantly increased 1 week after treatment compared with the baseline. Furthermore, the increased oxy-hemoglobin (oxy-Hb) values from the baseline to the one week after treatment was positively related to the total MADRAS 5-item score reductions in the left-hemispheric orbitofrontal cortex (<i>r</i> = - 0.307, <i>p</i> = 0.005). Our findings suggest that abnormal functional connectivity over OFC may reflect the pathophysiological characteristics of anhedonia and serve as a clinical biomarker for anhedonia.</p>

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The association between anhedonia and prefrontal cortex activation in patients with major depression: a functional near-infrared spectroscopy study

  • 期刊论文

  • 发表日期：

    2025年4月23日

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  • Li-Fen Chen,
  • Ching-En Lin,
  • Chi-Hsiang Chung,
  • Yong-An Chung,
  • Sonya Youngju Park,
  • Wei-Chou Chang,
  • Chuan-Chia Chang,
  • Hsin-An Chang

摘要

This study investigated cerebral blood flow characteristics using functional nearinfrared spectroscopy (fNIRS) in agomelatine-treated depressed patients with anhedonia. The level of anhedonia was assessed by the Snaith Hamilton Rating Scale (SHAPS) and Montgomery Åsberg Depression Rating Scale 5-item (MADRS 5-item) score. All 84 patients were evaluated on the day of the study initiation and followed at week 1, 4 and 8 after the study initiation. Graph theory-based network analysis showed 2-back task-modulated global efficiency (adjusted B = 0.055, 95% CI = 0.043 - 0.066) and local efficiency (adjusted B = 0.066, 95% CI = 0.050 - 0.081) were significantly increased 1 week after treatment compared with the baseline. Furthermore, the increased oxy-hemoglobin (oxy-Hb) values from the baseline to the one week after treatment was positively related to the total MADRAS 5-item score reductions in the left-hemispheric orbitofrontal cortex (r = - 0.307, p = 0.005). Our findings suggest that abnormal functional connectivity over OFC may reflect the pathophysiological characteristics of anhedonia and serve as a clinical biomarker for anhedonia.