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Background <p>Central compartment atopic disease (CCAD) is a subtype of chronic rhinosinusitis characterized by polypoid edema and mucosal changes localized to the central sinonasal compartment, particularly the middle turbinate, superior turbinate, and posterosuperior nasal septum, in association with inhalant allergy. Despite increasing recognition, its epidemiologic burden remains poorly defined.</p> Methods <p>All studies reporting the proportion of CCAD among CRS were extracted from OVID Medline, Scopus, and EBSCO CINAHL. A review of title and abstracts was done independently by seven reviewers. The quality of the studies was assessed using the Newcastle–Ottawa scale. Meta-analysis was performed using R v.4.1.1, using the ‘meta’, ‘tidyverse’, and ‘metafor’ packages (version 4.19–0).</p> Results <p>Seven studies from the United States and Asia were included in the study. The pooled proportion of CCAD was 23.0% (95% CI 15.0%–33.0%). Subgroup analyses suggested variability by region being higher in Asia and sex, showing higher prevalence in males; however, these analyses were exploratory in nature and intended to identify potential sources of heterogeneity rather than establish definitive subgroup differences.</p> Conclusion <p>CCAD represents a substantial proportion of chronic rhinosinusitis with nasal polyps (CRSwNP) cases globally, though estimates are limited by marked heterogeneity and inconsistent diagnostic criteria. Standardized case definitions and wider geographic surveillance are essential to better characterize the global burden and phenotypic diversity of CCAD.</p>

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Prevalence of Central Compartment Atopic Disease (CCAD): a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2026年5月29日

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  • Robbi Miguel G. Falcon,
  • Ma. Angela Diarota,
  • Ross Ivan T. Gammad,
  • Rona Angela D. Grindulo,
  • Gabrielle Anne P. Mata,
  • Christine B. Porras,
  • Mark Joseph R. Remucal,
  • Cyril Francis T. Wakit,
  • Kimberly Mae O. Nelson,
  • Teresa Luisa G. Cruz

摘要

Background

Central compartment atopic disease (CCAD) is a subtype of chronic rhinosinusitis characterized by polypoid edema and mucosal changes localized to the central sinonasal compartment, particularly the middle turbinate, superior turbinate, and posterosuperior nasal septum, in association with inhalant allergy. Despite increasing recognition, its epidemiologic burden remains poorly defined.

Methods

All studies reporting the proportion of CCAD among CRS were extracted from OVID Medline, Scopus, and EBSCO CINAHL. A review of title and abstracts was done independently by seven reviewers. The quality of the studies was assessed using the Newcastle–Ottawa scale. Meta-analysis was performed using R v.4.1.1, using the ‘meta’, ‘tidyverse’, and ‘metafor’ packages (version 4.19–0).

Results

Seven studies from the United States and Asia were included in the study. The pooled proportion of CCAD was 23.0% (95% CI 15.0%–33.0%). Subgroup analyses suggested variability by region being higher in Asia and sex, showing higher prevalence in males; however, these analyses were exploratory in nature and intended to identify potential sources of heterogeneity rather than establish definitive subgroup differences.

Conclusion

CCAD represents a substantial proportion of chronic rhinosinusitis with nasal polyps (CRSwNP) cases globally, though estimates are limited by marked heterogeneity and inconsistent diagnostic criteria. Standardized case definitions and wider geographic surveillance are essential to better characterize the global burden and phenotypic diversity of CCAD.