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Purpose <p>This scoping review aimed to synthesize current evidence on electrically evoked auditory brainstem responses (eABRs) in individuals with inner ear malformations (IEMs), with a focus on extraction rates, waveform characteristics, and clinical implications.</p> Methods <p>Following PRISMA-ScR and JBI guidelines, a systematic search was conducted in CINAHL, MEDLINE, EMBASE, and PubMed for studies published between January 2005 and June 2025. We included original research articles reporting eABR findings in participants with IEMs. Twenty-one studies met the eligibility criteria.</p> Results <p>eABRs were generally obtainable in children with IEMs, though higher thresholds and lower response detectability were frequently observed compared to peers with normal cochlear anatomy. Certain subtypes, such as common cavity and cochlear nerve canal stenosis, often exhibited elevated thresholds. Despite this, wave latency parameters often remained stable. Among patients with Incomplete Partition Type II (IP-II), eABR detectability varied considerably, indicating that cochlear size alone does not determine neural response strength. Factors such as stimulation site, electrode type, and timing of auditory input influenced eABR outcomes.</p> Conclusion <p>eABR is a useful tool for evaluating auditory pathway integrity in patients with IEMs. Elevated thresholds may reflect reduced neural synchrony, yet stable waveforms suggest retained function. Incorporating both anatomical and functional data may improve clinical interpretation and decision-making.</p>

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Neural response patterns in inner ear malformations: a scoping review of eABR findings

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月5日

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  • Sevgi Kadihanoglu,
  • Mehmet Yarali

摘要

Purpose

This scoping review aimed to synthesize current evidence on electrically evoked auditory brainstem responses (eABRs) in individuals with inner ear malformations (IEMs), with a focus on extraction rates, waveform characteristics, and clinical implications.

Methods

Following PRISMA-ScR and JBI guidelines, a systematic search was conducted in CINAHL, MEDLINE, EMBASE, and PubMed for studies published between January 2005 and June 2025. We included original research articles reporting eABR findings in participants with IEMs. Twenty-one studies met the eligibility criteria.

Results

eABRs were generally obtainable in children with IEMs, though higher thresholds and lower response detectability were frequently observed compared to peers with normal cochlear anatomy. Certain subtypes, such as common cavity and cochlear nerve canal stenosis, often exhibited elevated thresholds. Despite this, wave latency parameters often remained stable. Among patients with Incomplete Partition Type II (IP-II), eABR detectability varied considerably, indicating that cochlear size alone does not determine neural response strength. Factors such as stimulation site, electrode type, and timing of auditory input influenced eABR outcomes.

Conclusion

eABR is a useful tool for evaluating auditory pathway integrity in patients with IEMs. Elevated thresholds may reflect reduced neural synchrony, yet stable waveforms suggest retained function. Incorporating both anatomical and functional data may improve clinical interpretation and decision-making.