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Background <p>Clinical–pathological discordance in T staging is common in laryngeal squamous cell carcinoma (LSCC) and may affect treatment planning and prognosis. Its impact in patients treated with open partial horizontal laryngectomy (OPHL) remains unclear.</p> Methods <p>A retrospective multicenter study was conducted on 106 patients with glottic or supraglottic LSCC treated with OPHL. Discrepancies between clinical (cT) and pathological (pT) staging were analyzed. Associations with preoperative factors, adjuvant therapy, disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS) were evaluated.</p> Results <p>T-stage discordance was observed in 37.7% of patients, with 19.8% upstaged and 17.9% downstaged. No preoperative factor was significantly associated with discordance. T-stage discrepancy was not significantly associated with DFS, DSS, OS, or the need for adjuvant therapy.</p> Conclusion <p>In patients undergoing OPHL, clinical–pathological T-stage discordance does not appear to significantly affect oncologic outcomes, likely due to the modular and adaptable nature of the surgical procedure.</p>

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Clinical–pathological T-stage discrepancy in OPHL: impact on oncologic outcomes

  • 期刊论文

  • 发表日期：

    2026年5月13日

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  • Carlotta Liberale,
  • Sara Librio,
  • Edoardo Serafini,
  • Rocco Strangio,
  • Leonardo Roncadi,
  • Sara Bassani,
  • Giulia Querzoli,
  • Francesco Mattioli,
  • Daniele Marchioni,
  • Livio Presutti,
  • Gabriele Molteni,
  • Matteo Fermi

摘要

Background

Clinical–pathological discordance in T staging is common in laryngeal squamous cell carcinoma (LSCC) and may affect treatment planning and prognosis. Its impact in patients treated with open partial horizontal laryngectomy (OPHL) remains unclear.

Methods

A retrospective multicenter study was conducted on 106 patients with glottic or supraglottic LSCC treated with OPHL. Discrepancies between clinical (cT) and pathological (pT) staging were analyzed. Associations with preoperative factors, adjuvant therapy, disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS) were evaluated.

Results

T-stage discordance was observed in 37.7% of patients, with 19.8% upstaged and 17.9% downstaged. No preoperative factor was significantly associated with discordance. T-stage discrepancy was not significantly associated with DFS, DSS, OS, or the need for adjuvant therapy.

Conclusion

In patients undergoing OPHL, clinical–pathological T-stage discordance does not appear to significantly affect oncologic outcomes, likely due to the modular and adaptable nature of the surgical procedure.