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Purpose <p>Nasal irrigation has consistently demonstrated clinical benefits in sinonasal diseases. However, the influence of solution composition, particularly electrolytes, on epithelial function remains underexplored. This translational controlled blinded in vitro study examined how different mineralized saline affect nasal polyp epithelium, focusing on mucosal and immune responses.</p> Methods <p>Epithelia of nasal polyps from 39 patients were incubated in nine isotonic mineralized saline (pharmaceutical-grade mineral salts or natural seawater, neutral to moderately alkaline pH), normal saline, and control media, with and without dexamethasone. Outcomes included ciliary beat frequency (CBF), wound repair speed (WRS), and inflammatory marker reduction (IMR).</p> Results <p>Normal saline and the highly mineralized solution S9 showed the poorest CBF and WRS. Diluted seawater formulations S5 and S10 (30% seawater; S10 enriched with sulfate, magnesium, sulfur, calcium) achieved best WRS, with S10 excelling overall. Electrodialyzed seawater variants S11 and S12 (monovalent ions removed; S12 mineral-enriched) reached the highest CBF. The balanced pharmaceutical-grade eight-mineral solution S6, containing sodium, chloride, sulfate, magnesium, sulfur, calcium, potassium, and bicarbonates, maintained control-level CBF and matched S10 in WRS, outperforming sulfur- and sulfate-depleted S4. All mineralized and normal saline significantly reduced IMR after 4&#xa0;h versus media.</p> Conclusion <p>Electrolyte composition critically influences nasal mucosal function. Both depleted and over-mineralized solutions appeared suboptimal. Poor results with normal saline suggest possible shortcomings of normal saline. Diluted seawater S10 and balanced eight-mineral S6 demonstrated more favorable in-vitro outcomes and may represent promising candidates for optimizing nasal irrigation and respiratory epithelial health, pending clinical confirmation.</p>

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Electrolyte-rich saline solutions significantly improve nasal epithelial repair, ciliary beating and epithelial inflammation vs. normal saline

  • 期刊论文

  • 发表日期：

    2026年4月6日

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  • Ludovic de Gabory,
  • Christelle Coraux,
  • Anne Beaulieu,
  • Mélodie Kerimian

摘要

Purpose

Nasal irrigation has consistently demonstrated clinical benefits in sinonasal diseases. However, the influence of solution composition, particularly electrolytes, on epithelial function remains underexplored. This translational controlled blinded in vitro study examined how different mineralized saline affect nasal polyp epithelium, focusing on mucosal and immune responses.

Methods

Epithelia of nasal polyps from 39 patients were incubated in nine isotonic mineralized saline (pharmaceutical-grade mineral salts or natural seawater, neutral to moderately alkaline pH), normal saline, and control media, with and without dexamethasone. Outcomes included ciliary beat frequency (CBF), wound repair speed (WRS), and inflammatory marker reduction (IMR).

Results

Normal saline and the highly mineralized solution S9 showed the poorest CBF and WRS. Diluted seawater formulations S5 and S10 (30% seawater; S10 enriched with sulfate, magnesium, sulfur, calcium) achieved best WRS, with S10 excelling overall. Electrodialyzed seawater variants S11 and S12 (monovalent ions removed; S12 mineral-enriched) reached the highest CBF. The balanced pharmaceutical-grade eight-mineral solution S6, containing sodium, chloride, sulfate, magnesium, sulfur, calcium, potassium, and bicarbonates, maintained control-level CBF and matched S10 in WRS, outperforming sulfur- and sulfate-depleted S4. All mineralized and normal saline significantly reduced IMR after 4 h versus media.

Conclusion

Electrolyte composition critically influences nasal mucosal function. Both depleted and over-mineralized solutions appeared suboptimal. Poor results with normal saline suggest possible shortcomings of normal saline. Diluted seawater S10 and balanced eight-mineral S6 demonstrated more favorable in-vitro outcomes and may represent promising candidates for optimizing nasal irrigation and respiratory epithelial health, pending clinical confirmation.