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Purpose <p>This review aims to analyze the literature concerning multimodal treatments for Obstructive Sleep Apnea.</p> Methods <p>The outcomes of interest were Apnea–Hypopnea Index (AHI) reduction, Epworth Sleepiness Scale (ESS) reduction and improved Continous Positive Airway Pressure (CPAP) treatment adherence. 47 studies were selected for the statistical analysis.</p> Results <p>Related to the AHI reduction, the results showed a significantly greater reduction with multimodal interventions compared to single therapies (Z = -3.981; <i>p</i> &lt; 0.05). For the ESS reduction, the overall effect size was -0.618 (Z = -2.464; <i>p</i> &lt; 0.05), indicating that multimodal approaches provided a significantly greater reduction in ESS than single treatments. For the CPAP adherence the pooled effect size was 0.607 (Z = 2.341; <i>p</i> &lt; 0.05) indicating that multimodal strategies significantly increased CPAP use compared to single treatments.</p> Conclusions <p>Multimodal approaches for OSA patients represent a promising treatment strategy, highlighting the superiority of combined treatments over single strategy, and emphasizing the importance of a patient-tailored therapeutic decision-making process.</p>

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Maximizing outcomes by multimodal treatment in obstructive sleep apnea: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2025年11月23日

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  • Andrea De Vito,
  • Aniello Donniacuo,
  • Giovanni Cammaroto,
  • Giuseppe Meccariello,
  • Cristina Baroni,
  • Antonio Andrade,
  • Marco Mandalà,
  • Jerome R. Lechien,
  • Ewa Olszewska

摘要

Purpose

This review aims to analyze the literature concerning multimodal treatments for Obstructive Sleep Apnea.

Methods

The outcomes of interest were Apnea–Hypopnea Index (AHI) reduction, Epworth Sleepiness Scale (ESS) reduction and improved Continous Positive Airway Pressure (CPAP) treatment adherence. 47 studies were selected for the statistical analysis.

Results

Related to the AHI reduction, the results showed a significantly greater reduction with multimodal interventions compared to single therapies (Z = -3.981; p < 0.05). For the ESS reduction, the overall effect size was -0.618 (Z = -2.464; p < 0.05), indicating that multimodal approaches provided a significantly greater reduction in ESS than single treatments. For the CPAP adherence the pooled effect size was 0.607 (Z = 2.341; p < 0.05) indicating that multimodal strategies significantly increased CPAP use compared to single treatments.

Conclusions

Multimodal approaches for OSA patients represent a promising treatment strategy, highlighting the superiority of combined treatments over single strategy, and emphasizing the importance of a patient-tailored therapeutic decision-making process.