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Purpose <p>This study investigated the vocal characteristics of children receiving GH treatment.</p> Methods <p>This analytical, observational cohort study include 57 paediatric patients (33 males and 24 females). Females and males were divided into two groups: prepubertal and pubertal. Voice recordings were obtained from all patients at pretreatment, 3 months posttreatment and 6 months posttreatment. Acoustic analyses were conducted using the Dr. Speech software, and the fundamental frequency (F0), jitter, shimmer, harmonic-to-noise ratio (HNR), and maximum phonation time (MPT) were evaluated.</p> Results <p>In prepubertal and pubertal males, a significant decrease in F0 values was observed between the pre- and posttreatment periods and between the 3- and 6-month assessments. In prepubertal females, there was a statistically significant difference between the pre- and posttreatment periods, but there was no significant difference was found between the 3- and 6-month assessments. In pubertal females, no significant difference in f0 values was found between the groups. No significant differences in the jitter or shimmer values were observed between groups. The HNR values were not statistically significant. While there was a general improvement in MPT, this prolongation was significant among females.</p> Conclusion <p>GH treatment causes changes in vocal characteristics by changing acoustic parameters, even within a short time. These changes are important for the social development of children. Our study is the largest number of patients reporting acoustic analysis results in children receiving GH treatment in the literature. For this reason, it is important due to the reliability of the results and their contribution to science.</p>

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Changes in vocal characteristics among children receiving growth hormone treatment due to isolated growth hormone deficiency

  • 期刊论文

  • 发表日期：

    2025年10月24日

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  • Ozan Tuysuz,
  • Zumrut Kocabey Sutcu,
  • Selin Ustun Bezgin,
  • Emel Hatun Aytac Kaplan,
  • Ridvan Basaran,
  • Semih Tekin,
  • Sahin Ogreden,
  • Ozgur Yigit

摘要

Purpose

This study investigated the vocal characteristics of children receiving GH treatment.

Methods

This analytical, observational cohort study include 57 paediatric patients (33 males and 24 females). Females and males were divided into two groups: prepubertal and pubertal. Voice recordings were obtained from all patients at pretreatment, 3 months posttreatment and 6 months posttreatment. Acoustic analyses were conducted using the Dr. Speech software, and the fundamental frequency (F0), jitter, shimmer, harmonic-to-noise ratio (HNR), and maximum phonation time (MPT) were evaluated.

Results

In prepubertal and pubertal males, a significant decrease in F0 values was observed between the pre- and posttreatment periods and between the 3- and 6-month assessments. In prepubertal females, there was a statistically significant difference between the pre- and posttreatment periods, but there was no significant difference was found between the 3- and 6-month assessments. In pubertal females, no significant difference in f0 values was found between the groups. No significant differences in the jitter or shimmer values were observed between groups. The HNR values were not statistically significant. While there was a general improvement in MPT, this prolongation was significant among females.

Conclusion

GH treatment causes changes in vocal characteristics by changing acoustic parameters, even within a short time. These changes are important for the social development of children. Our study is the largest number of patients reporting acoustic analysis results in children receiving GH treatment in the literature. For this reason, it is important due to the reliability of the results and their contribution to science.