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Purpose <p>Sinonasal osteoblastoma is a rare benign tumor that can involve critical structures like the skull base and orbit. This study presents a case series and literature review to describe clinical features, surgical management, and outcomes.</p> Methods <p>Five patients with sinonasal osteoblastoma were treated endoscopically between 2020 and 2025. Clinical data, imaging, surgical approach, histopathology, and follow-up outcomes were reviewed. A PubMed search was conducted to identify previously reported cases.</p> Results <p>Patients ranged from 12 to 57 years old. Tumors most commonly involved the ethmoid sinus and presented with nasal obstruction, headache, or epistaxis. Four underwent total endoscopic resection; one had subtotal removal due to frontal sinus involvement. Histopathology revealed three conventional and two aggressive osteoblastomas. No recurrences or major complications occurred over a follow-up of two to five years.</p> Conclusion <p>Endoscopic resection appears to be a safe and effective approach for sinonasal osteoblastomas, even in cases with skull base or orbital extension. This series supports the growing role of minimally invasive surgery in managing these uncommon tumors.</p>

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Sinonasal osteoblastoma: a case series and comprehensive literature review

  • 期刊论文

  • 发表日期：

    2025年12月6日

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  • Goran Latif Omer,
  • Aland Salih Abdullah,
  • Sahand Soran Ali,
  • Stefano Di Girolamo,
  • Sveva Viola,
  • Andrea Bravetti,
  • Maria Grazia Maglie,
  • Erika Massimi,
  • Sara Maurantonio,
  • Davide Balletta,
  • Laura Borghesi,
  • Mahabad Abdalaziz Salih,
  • Giuseppe De Donato

摘要

Purpose

Sinonasal osteoblastoma is a rare benign tumor that can involve critical structures like the skull base and orbit. This study presents a case series and literature review to describe clinical features, surgical management, and outcomes.

Methods

Five patients with sinonasal osteoblastoma were treated endoscopically between 2020 and 2025. Clinical data, imaging, surgical approach, histopathology, and follow-up outcomes were reviewed. A PubMed search was conducted to identify previously reported cases.

Results

Patients ranged from 12 to 57 years old. Tumors most commonly involved the ethmoid sinus and presented with nasal obstruction, headache, or epistaxis. Four underwent total endoscopic resection; one had subtotal removal due to frontal sinus involvement. Histopathology revealed three conventional and two aggressive osteoblastomas. No recurrences or major complications occurred over a follow-up of two to five years.

Conclusion

Endoscopic resection appears to be a safe and effective approach for sinonasal osteoblastomas, even in cases with skull base or orbital extension. This series supports the growing role of minimally invasive surgery in managing these uncommon tumors.