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Purpose <p>To assess the safety of methylprednisolone irrigation in the ductal system of salivary glands during sialendoscopy and its impact on the hypothalamic-pituitary-adrenal (HPA) axis.</p> Methods <p>Nineteen patients with non-lithiasic sialadenitis were included. Sialendoscopy was performed on the most affected gland (11 parotid, 8 submandibular glands), with 60&#xa0;mg of methylprednisolone in a 5&#xa0;ml solution of 0.9% NaCl saline irrigated into the ductal system. Serum cortisol and methylprednisolone concentrations were measured before irrigation, at 2 and 24&#xa0;h (h) post-irrigation. Patients were examined for post-interventional symptoms and signs 24&#xa0;h later.</p> Results <p>Serum cortisol concentrations increased at 2&#xa0;h (<i>p</i> &lt; 0.05), followed by a decrease (<i>p</i> &lt; 0.01) at 24&#xa0;h. Decrease was recorded in serum cortisol from 0&#xa0;h to 24&#xa0;h (17.2 ± 5.9 vs. 9.2 ± 8.0&#xa0;µg/dl, respectively, <i>p</i> &lt; 0.01); 37% of patients fulfilled the criteria for HPA axis suppression (serum cortisol ≤ 1.8&#xa0;µg/dl). A similar pattern for serum cortisol was observed for the parotid and submandibular glands separately, with more pronounced decrease in the parotid. Serum methylprednisolone increased at 2&#xa0;h, followed by a decrease to minimal concentrations at 24&#xa0;h. Pain during methylprednisolone irrigation was reported in 57.9% of patients. Blood pressure and glucose concentrations remained unaffected, and no other symptoms were reported.</p> Conclusion <p>Methylprednisolone irrigation during sialendoscopy caused biochemical HPA axis suppression in 37% of patients after 24&#xa0;h. However, the procedure is considered safe, as there were no reported cases of clinical hypocortisolemia. The decrease in serum cortisol at 24&#xa0;h was observed mainly after parotid gland irrigation. Minimal drug concentrations were found in the serum after 24&#xa0;h.</p>

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Safety of methylprednisolone irrigation during sialendoscopy: effects on the hypothalamic-pituitary-adrenal axis

  • 期刊论文

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  • 发表日期：

    2025年9月23日

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  • Konstantinos Garefis,
  • Angelos Chatziavramidis,
  • Dimitrios Goulis,
  • Vasileios Nikolaidis,
  • Konstantinos Markou,
  • Iordanis Konstantinidis

摘要

Purpose

To assess the safety of methylprednisolone irrigation in the ductal system of salivary glands during sialendoscopy and its impact on the hypothalamic-pituitary-adrenal (HPA) axis.

Methods

Nineteen patients with non-lithiasic sialadenitis were included. Sialendoscopy was performed on the most affected gland (11 parotid, 8 submandibular glands), with 60 mg of methylprednisolone in a 5 ml solution of 0.9% NaCl saline irrigated into the ductal system. Serum cortisol and methylprednisolone concentrations were measured before irrigation, at 2 and 24 h (h) post-irrigation. Patients were examined for post-interventional symptoms and signs 24 h later.

Results

Serum cortisol concentrations increased at 2 h (p < 0.05), followed by a decrease (p < 0.01) at 24 h. Decrease was recorded in serum cortisol from 0 h to 24 h (17.2 ± 5.9 vs. 9.2 ± 8.0 µg/dl, respectively, p < 0.01); 37% of patients fulfilled the criteria for HPA axis suppression (serum cortisol ≤ 1.8 µg/dl). A similar pattern for serum cortisol was observed for the parotid and submandibular glands separately, with more pronounced decrease in the parotid. Serum methylprednisolone increased at 2 h, followed by a decrease to minimal concentrations at 24 h. Pain during methylprednisolone irrigation was reported in 57.9% of patients. Blood pressure and glucose concentrations remained unaffected, and no other symptoms were reported.

Conclusion

Methylprednisolone irrigation during sialendoscopy caused biochemical HPA axis suppression in 37% of patients after 24 h. However, the procedure is considered safe, as there were no reported cases of clinical hypocortisolemia. The decrease in serum cortisol at 24 h was observed mainly after parotid gland irrigation. Minimal drug concentrations were found in the serum after 24 h.